Problemas relacionados a medicamentos na antiemese de gestantes hospitalizadas

Introduction: High-risk pregnant women are more likely to develop nausea and vomiting in pregnancy requiring therapy with antiemetics that can lead to drug-related problems (DRPs). Objective: To characterize the profile, occurrence and duration of DRPs of the main antiemetics used in hospitalized hi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Autor principal: Matias, Victoria Hanna Braga
Outros Autores: Martins, Rand Randall
Formato: bachelorThesis
Idioma:pt_BR
Publicado em: Universidade Federal do Rio Grande do Norte
Assuntos:
farmacovigilância
segurança do paciente
gestação de alto risco
ondansetrona
metoclopramida
patient safety
pharmacovigilance
high-risk pregnancy
ondansetron
metoclopramide
CNPQ::CIENCIAS DA SAUDE::FARMACIA
Endereço do item:https://repositorio.ufrn.br/handle/123456789/49994
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id ri-123456789-49994
record_format dspace
institution Repositório Institucional
collection RI - UFRN
language pt_BR
topic farmacovigilância
segurança do paciente
gestação de alto risco
ondansetrona
metoclopramida
patient safety
pharmacovigilance
high-risk pregnancy
ondansetron
metoclopramide
CNPQ::CIENCIAS DA SAUDE::FARMACIA
spellingShingle farmacovigilância
segurança do paciente
gestação de alto risco
ondansetrona
metoclopramida
patient safety
pharmacovigilance
high-risk pregnancy
ondansetron
metoclopramide
CNPQ::CIENCIAS DA SAUDE::FARMACIA
Matias, Victoria Hanna Braga
Problemas relacionados a medicamentos na antiemese de gestantes hospitalizadas
description Introduction: High-risk pregnant women are more likely to develop nausea and vomiting in pregnancy requiring therapy with antiemetics that can lead to drug-related problems (DRPs). Objective: To characterize the profile, occurrence and duration of DRPs of the main antiemetics used in hospitalized high-risk pregnant women. Methods: This study was approved by the Institutional Research Ethics Committee with the consent of all participants. Prospective observational cohort study involving 547 high-risk pregnant women, with a mean age of 30.4 ± 6.6 years, hospitalized in a teaching maternity hospital and evaluated between August 2019 and August 2021. Data collection was performed daily through prescription analysis, active research in medical records, pharmaceutical anamnesis and classification of DRPs. For statistical analysis of the data, the program Stata version 13, Pearson's chi-square and Student's t-test (p<0.05) were used. Results: Among the 547 participants, 345 (63.1%) used antiemetics. The most prescribed were ondansetron (88.5%) and metoclopramide (9.0%), both injectable. Both drugs presented DRP of therapeutic ineffectiveness, being higher with metoclopramide (13.5%) compared to ondansetron (4.8%). As for the duration of MRP, ondansetron and metoclopramide required 4.7 and 2.4 days, respectively. Conclusion: The use of antiemetics by hospitalized pregnant women is high, especially ondansetron. DRPs of ineffectiveness and duration were found. Compared to metoclopramide, ondansetron is more effective, although it takes longer to reverse emesis.
author2 Martins, Rand Randall
author_facet Martins, Rand Randall
Matias, Victoria Hanna Braga
format bachelorThesis
author Matias, Victoria Hanna Braga
author_sort Matias, Victoria Hanna Braga
title Problemas relacionados a medicamentos na antiemese de gestantes hospitalizadas
title_short Problemas relacionados a medicamentos na antiemese de gestantes hospitalizadas
title_full Problemas relacionados a medicamentos na antiemese de gestantes hospitalizadas
title_fullStr Problemas relacionados a medicamentos na antiemese de gestantes hospitalizadas
title_full_unstemmed Problemas relacionados a medicamentos na antiemese de gestantes hospitalizadas
title_sort problemas relacionados a medicamentos na antiemese de gestantes hospitalizadas
publisher Universidade Federal do Rio Grande do Norte
publishDate 2022
url https://repositorio.ufrn.br/handle/123456789/49994
work_keys_str_mv AT matiasvictoriahannabraga problemasrelacionadosamedicamentosnaantiemesedegestanteshospitalizadas
AT matiasvictoriahannabraga drugrelatedproblemsintheantiemesisofhospitalizedpregnantwomen
_version_ 1773962306727706624
spelling ri-123456789-499942022-12-06T19:42:46Z Problemas relacionados a medicamentos na antiemese de gestantes hospitalizadas Drug-related problems in the antiemesis of hospitalized pregnant women Matias, Victoria Hanna Braga Martins, Rand Randall http://lattes.cnpq.br/7591293258752456 https://orcid.org/0000-0001-9668-0482 Fonseca, Andreia Suelle Moura Pereira, Ney Moura Lemos Farias, Andrezza Duarte farmacovigilância segurança do paciente gestação de alto risco ondansetrona metoclopramida patient safety pharmacovigilance high-risk pregnancy ondansetron metoclopramide CNPQ::CIENCIAS DA SAUDE::FARMACIA Introduction: High-risk pregnant women are more likely to develop nausea and vomiting in pregnancy requiring therapy with antiemetics that can lead to drug-related problems (DRPs). Objective: To characterize the profile, occurrence and duration of DRPs of the main antiemetics used in hospitalized high-risk pregnant women. Methods: This study was approved by the Institutional Research Ethics Committee with the consent of all participants. Prospective observational cohort study involving 547 high-risk pregnant women, with a mean age of 30.4 ± 6.6 years, hospitalized in a teaching maternity hospital and evaluated between August 2019 and August 2021. Data collection was performed daily through prescription analysis, active research in medical records, pharmaceutical anamnesis and classification of DRPs. For statistical analysis of the data, the program Stata version 13, Pearson's chi-square and Student's t-test (p<0.05) were used. Results: Among the 547 participants, 345 (63.1%) used antiemetics. The most prescribed were ondansetron (88.5%) and metoclopramide (9.0%), both injectable. Both drugs presented DRP of therapeutic ineffectiveness, being higher with metoclopramide (13.5%) compared to ondansetron (4.8%). As for the duration of MRP, ondansetron and metoclopramide required 4.7 and 2.4 days, respectively. Conclusion: The use of antiemetics by hospitalized pregnant women is high, especially ondansetron. DRPs of ineffectiveness and duration were found. Compared to metoclopramide, ondansetron is more effective, although it takes longer to reverse emesis. Introdução: Gestantes de alto risco são mais susceptíveis a desenvolver náuseas e vômitos na gravidez necessitando de terapia com antieméticos que podem levar ao aparecimento de problemas relacionados a medicamentos (PRMs). Objetivo: Caracterizar o perfil, ocorrência e duração de PRMs dos principais antieméticos utilizados em gestantes de alto risco hospitalizadas. Métodos: Esse estudo recebeu aprovação do Comitê de Ética e Pesquisa Institucional com consentimento de todas as participantes. Estudo observacional de coorte prospectivo envolvendo 547 gestantes de alto risco, com idade média 30,4 ± 6,6 anos, internadas em uma maternidade escola e avaliadas entre agosto de 2019 a agosto de 2021. A coleta de dados foi feita diariamente por meio de análise de prescrição, pesquisa ativa em prontuários, anamnese farmacêutica e classificação dos PRMs. Para as análises estatísticas dos dados foram utilizados o programa Stata versão 13, Qui-quadrado de Pearson e Teste T de Student (p<0,05). Resultados: Entre as 547 participantes, 345 (63,1%) faziam uso de antieméticos. Os mais prescritos foram ondansetrona (88,5%) e metoclopramida (9,0%), ambos injetáveis. Os dois fármacos apresentaram PRM de inefetividade terapêutica, sendo maior com a metoclopramida (13,5%) em comparação a ondansetrona (4,8%). Quanto a duração do PRM, a ondansetrona e a metoclopramida, demandaram respectivamente, 4,7 e 2,4 dias. Conclusão: O uso de antieméticos por gestantes hospitalizadas é elevado, sobretudo ondansetrona. Foram encontrados PRMs de inefetividade e duração. Comparada a metoclopramida, a ondasentrona é mais efetiva, apesar de demandar mais tempo para reverter quadro de emese. 2022-12-06T19:42:46Z 2022-12-06T19:42:46Z 2022-11-25 bachelorThesis MATIAS, Victoria Hanna Braga. Problemas relacionados a medicamentos na antiemese de gestantes hospitalizadas. 2022. 24f. Trabalho de Conclusão de Curso (Graduação em Farmácia), Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2022. https://repositorio.ufrn.br/handle/123456789/49994 pt_BR Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Universidade Federal do Rio Grande do Norte Brasil UFRN Bacharelado em Farmácia Faculdade de Farmácia

Registros relacionados