Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior

Observational studies of long-term users of ayahuasca, an Amazonian psychedelic brew, suggest an increase in resilience via improvements in emotion and cognition. Ayahuasca has also demonstrated clinical antidepressant effects in human and animal studies; however, its potential prophylactic action i...

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Principais autores:	Grilo, Maria Lara Porpino de Meiroz, Sousa, Geovan Menezes de, Mendonça, Lilían Andrade Carlos de, Soares, Bruno Lobão, Sousa, Maria Bernardete Cordeiro de, Fontes, Fernanda Palhano Xavier de, Araujo, Draulio Barros de, Perkins, Daniel, Hallak, Jaime Eduardo Cecilio, Coelho, Nicole Leite Galvão
Formato:	article
Idioma:	English
Publicado em:	Frontiers Media SA
Assuntos:	Ayahuasca - Resilience Ayahuasca - Prophylaxis Hallucinogens - Therapeutic use Depression - Drug therapy Depressive disorder - Drug therapy Depressive disorder, major - Drug therapy Callithrix
Endereço do item:	https://repositorio.ufrn.br/handle/123456789/49867
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spelling	ri-123456789-498672022-11-24T13:26:41Z Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior Grilo, Maria Lara Porpino de Meiroz Sousa, Geovan Menezes de Mendonça, Lilían Andrade Carlos de Soares, Bruno Lobão Sousa, Maria Bernardete Cordeiro de Fontes, Fernanda Palhano Xavier de Araujo, Draulio Barros de Perkins, Daniel Hallak, Jaime Eduardo Cecilio Coelho, Nicole Leite Galvão Ayahuasca - Resilience Ayahuasca - Prophylaxis Hallucinogens - Therapeutic use Depression - Drug therapy Depressive disorder - Drug therapy Depressive disorder, major - Drug therapy Callithrix Observational studies of long-term users of ayahuasca, an Amazonian psychedelic brew, suggest an increase in resilience via improvements in emotion and cognition. Ayahuasca has also demonstrated clinical antidepressant effects in human and animal studies; however, its potential prophylactic action in depression has not been previously studied. Therefore, this experimental study sought to evaluate the potential prophylactic effects of repeated and long-term ayahuasca use, via the modulation of resilience, in a non-human primate animal model, Callithrix jacchus, subjected to a protocol for induction of depressive-like behavior. For the formation of the study groups, some juvenile marmosets were kept in their family groups (GF = 7), while for the two experimental groups, the animals were removed from the family and kept socially isolated. Then, part of the isolated animals made up the group in which ayahuasca was administered (AG, n = 6), while for others, no intervention was made (IG, n = 5). AG animals took ayahuasca (1.67 mL/300g body weight) at weeks 4 (before isolation), 8, and 12 (during isolation) of the study. More adaptive stress response was observed for the AG when compared to the IG. The AG showed higher cortisol reactivity and fecal cortisol levels than IG, while both measures were similar to FG. Moreover, AG animals showed no signs of anhedonia and no increase in chronic stress-related behaviors, which were expressed by the IG. Thus, ayahuasca seems to promote the expression of resilient responses, indicating a prophylactic action, buffering the emergence of depressive-like behaviors and cortisol alterations associated with major depression. These results are encouraging for further research on the prophylactic use of psychedelics to prevent psychopathologies associated with chronic stress 2022-11-24T13:26:40Z 2022-11-24T13:26:40Z 2022-11 article GRILO, Maria Lara Porpino de Meiroz; SOUSA, Geovan Menezes de; MENDONÇA, Lilían Andrade Carlos de; LOBÃO-SOARES, Bruno; SOUSA, Maria Bernardete Cordeiro de; PALHANO-FONTES, Fernanda; ARAUJO, Draulio Barros de; PERKINS, Daniel; HALLAK, Jaime Eduardo Cecilio; GALVÃO-COELHO, Nicole Leite. Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior. Frontiers In Behavioral Neuroscience, [S. l.], v. 16, p. 901425, nov. 2022. Doi: http://dx.doi.org/10.3389/fnbeh.2022.901425. Disponível em: https://www.frontiersin.org/articles/10.3389/fnbeh.2022.901425/full. Acesso em: 24 nov. 2022 https://repositorio.ufrn.br/handle/123456789/49867 10.3389/fnbeh.2022.901425 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Frontiers Media SA
institution	Repositório Institucional
collection	RI - UFRN
language	English
topic	Ayahuasca - Resilience Ayahuasca - Prophylaxis Hallucinogens - Therapeutic use Depression - Drug therapy Depressive disorder - Drug therapy Depressive disorder, major - Drug therapy Callithrix
spellingShingle	Ayahuasca - Resilience Ayahuasca - Prophylaxis Hallucinogens - Therapeutic use Depression - Drug therapy Depressive disorder - Drug therapy Depressive disorder, major - Drug therapy Callithrix Grilo, Maria Lara Porpino de Meiroz Sousa, Geovan Menezes de Mendonça, Lilían Andrade Carlos de Soares, Bruno Lobão Sousa, Maria Bernardete Cordeiro de Fontes, Fernanda Palhano Xavier de Araujo, Draulio Barros de Perkins, Daniel Hallak, Jaime Eduardo Cecilio Coelho, Nicole Leite Galvão Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior
description	Observational studies of long-term users of ayahuasca, an Amazonian psychedelic brew, suggest an increase in resilience via improvements in emotion and cognition. Ayahuasca has also demonstrated clinical antidepressant effects in human and animal studies; however, its potential prophylactic action in depression has not been previously studied. Therefore, this experimental study sought to evaluate the potential prophylactic effects of repeated and long-term ayahuasca use, via the modulation of resilience, in a non-human primate animal model, Callithrix jacchus, subjected to a protocol for induction of depressive-like behavior. For the formation of the study groups, some juvenile marmosets were kept in their family groups (GF = 7), while for the two experimental groups, the animals were removed from the family and kept socially isolated. Then, part of the isolated animals made up the group in which ayahuasca was administered (AG, n = 6), while for others, no intervention was made (IG, n = 5). AG animals took ayahuasca (1.67 mL/300g body weight) at weeks 4 (before isolation), 8, and 12 (during isolation) of the study. More adaptive stress response was observed for the AG when compared to the IG. The AG showed higher cortisol reactivity and fecal cortisol levels than IG, while both measures were similar to FG. Moreover, AG animals showed no signs of anhedonia and no increase in chronic stress-related behaviors, which were expressed by the IG. Thus, ayahuasca seems to promote the expression of resilient responses, indicating a prophylactic action, buffering the emergence of depressive-like behaviors and cortisol alterations associated with major depression. These results are encouraging for further research on the prophylactic use of psychedelics to prevent psychopathologies associated with chronic stress
format	article
author	Grilo, Maria Lara Porpino de Meiroz Sousa, Geovan Menezes de Mendonça, Lilían Andrade Carlos de Soares, Bruno Lobão Sousa, Maria Bernardete Cordeiro de Fontes, Fernanda Palhano Xavier de Araujo, Draulio Barros de Perkins, Daniel Hallak, Jaime Eduardo Cecilio Coelho, Nicole Leite Galvão
author_facet	Grilo, Maria Lara Porpino de Meiroz Sousa, Geovan Menezes de Mendonça, Lilían Andrade Carlos de Soares, Bruno Lobão Sousa, Maria Bernardete Cordeiro de Fontes, Fernanda Palhano Xavier de Araujo, Draulio Barros de Perkins, Daniel Hallak, Jaime Eduardo Cecilio Coelho, Nicole Leite Galvão
author_sort	Grilo, Maria Lara Porpino de Meiroz
title	Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior
title_short	Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior
title_full	Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior
title_fullStr	Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior
title_full_unstemmed	Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior
title_sort	prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior
publisher	Frontiers Media SA
publishDate	2022
url	https://repositorio.ufrn.br/handle/123456789/49867
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Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior

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