Alcaloides de Erythrina velutina como possíveis agentes bioativos para transtornos cognitivos
Alzheimer’s disease (AD) is characterized by a neurodegenerative disorder that causes irreversible memory loss, being the main cause of dementia in the elderly population. Memory is a key function for our everyday life and AD therapy can only improve quality of life but does not prevent the progr...
সংরক্ষণ করুন:
| প্রধান লেখক: | |
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| অন্যান্য লেখক: | |
| বিন্যাস: | Dissertação |
| ভাষা: | pt_BR |
| প্রকাশিত: |
Universidade Federal do Rio Grande do Norte
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://repositorio.ufrn.br/handle/123456789/49743 |
| ট্যাগগুলো: |
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| সংক্ষিপ্ত: | Alzheimer’s disease (AD) is characterized by a neurodegenerative
disorder that causes irreversible memory loss, being the main cause of dementia
in the elderly population. Memory is a key function for our everyday life and AD
therapy can only improve quality of life but does not prevent the progression of
disease and symptoms. The therapeutic arsenal for the treatment of this disease
is limited to some substances with action in the inhibition of the enzyme
cholinesterase, which blocks the effects of acetylcholine reduction, resulting in
neuroprotection. Therefore, new natural product options become interesting. Due
to the great biodiversity of medicinal plants found in Brazil, mainly in the Caatinga
biome that is exclusive to the Brazilian territory. Erythrina velutina is one of these
plants with bioactive potential, which has a popular therapeutic use and has in its
composition isoquinolinic alkaloids that have demonstrated psychoactive
activities. Thus, the objective of this study was to evaluate the in vivo biological
potential of fractions enriched in E. velutina seed alkaloids on cognitive aspects
using as an experimental model the zebrafish (Danio rerio). A fraction enriched
in alkaloids was obtained from the seeds of the plant, which was used in zebrafish
biological tests for toxicological evaluation in embryos and adults. The fraction
has a lethal concentration for embryos at 17.40ug/ml but is not toxic to adults. In
adults, the fraction caused a response of decreased anxiety-type behavior. In
short-term memory tests, treatment with the fraction improved the performance
of the animals, but no action of the long-term memory fraction was observed. At
the end of this study, we observed that the fraction enriched in alkaloids presents
anxiolytic potential and improves the short-term mnemonic response, thus
showing bioactive potential in the face of memory-related aspects. |
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