Efeitos da deficiência crônica em ácidos graxos essenciais sobre a expressão do ritmo circadiano da atividade locomotora em ratos
Considering the importance of circadian rhythms to the survival of organisms and the vulnerability of the nervous system to environmental and nutrition changes, this study was developed aiming to evaluate the effects of a diet deficient in essential fatty acids, omega-3 and omega-6, in rats exposed...
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| Formato: | doctoralThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/49466 |
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| Resumo: | Considering the importance of circadian rhythms to the survival of organisms and the vulnerability of the nervous system to environmental and nutrition changes, this study was developed aiming to evaluate the effects of a diet deficient in essential fatty acids, omega-3 and omega-6, in rats exposed to different lighting regimes on the circadian rhythmicity. Wistar rats from postnatal ages P21 to P125 were fed control or deficient in EFAs diets in ad libitum settings, being kept at controlled temperature (average 21 ± 2 ° C) and lighting (with luminance of 150 lux during the and 1 lux of light during the dark) in a light-dark cycle of 24 hours (LD 12:12) and subsequently subjected to phase delay and constant darkness, where their motor activity was recorded continuously monitored by infrared sensors sensitive to movement. The analysis of the pace and plotting of graphs (actograms and periodograms) was performed using the program "El Temps®". One of the observations found in the treatment with the experimental diet was the capability to reduce the motor activity during the light phase (p <0.01) and the longer time required by the animal to resynchronize after the 6 h phase delay of the light-dark cycle 6 h dark (p <0.05) in young rats. Adult animals treated with the experimental diet were, after P84, unable to resynchronize the motor activity for the light-dark cycle, therefore presenting an increase in the period (1478 ± 9.67 min, p <0.01) when compared to control (1442 ± 1.3 min). In free running conditions, after P105, there is variation in the period, with predominance towards the experimental group (p<0,05). These results are consistent with the idea that the functional organization of the circadian system can be modified by the lipid composition of the diet, including saturated fatty acids, and outlines a modulating role of polyunsaturated fatty acids in synchronization induced by light in the circadian system. |
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