Abordagem baseada em Quality by Design (QbD) para desenvolvimento de microemulsão contendo óleo de Passiflora setacea
Microemulsions are nanoscale systems, particularly between 10 and 100 nm, capable of carrying natural oils and improving their organoleptic characteristics. The fixed oil obtained from Passiflora setacea stands out among others for its composition rich in unsaturated fatty acids of the omega fami...
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| Format: | Dissertação |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Accés en línia: | https://repositorio.ufrn.br/handle/123456789/49232 |
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| Sumari: | Microemulsions are nanoscale systems, particularly between 10 and 100 nm,
capable of carrying natural oils and improving their organoleptic characteristics.
The fixed oil obtained from Passiflora setacea stands out among others for its
composition rich in unsaturated fatty acids of the omega family, endowed with
therapeutic potential, such as wound healing. Thus, the aim of this work was to
use the ideals of Quality by Design for the development of a formulation based
on microemulsified systems. Initially, the fixed oil from P. setacea seeds was
extracted using the Soxhlet method and had its chemical composition
characterized using Gas chromatography–mass spectrometry. Then, designs of
experiments were used to identify the ideal composition of oil, surfactants, and
ratio of surfactants in relation to hydrodynamic droplet diameter, polydispersity
index and visual classification. The exploratory linear planning models were not
significant, indicating the possible presence of curvature. The Box-Behnken
design was satisfactory in predicting the influence of factors and their interactions,
the model has r2 of 0.99, 0.91 and 0.97, for hydrodynamic diameter,
polydispersity index and visual classification, respectively. Through the response
surface and the desirability profile, it was possible to develop an optimized
system, followed by its improvement for the topical route. These systems retained
their physicochemical stability for 60 days, with a good prognosis to be further
investigated for activity and toxicity. |
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