Avaliação in silico da afinidade de drogas ao receptor TRPA1 como preditor para o manejo farmacológico da sensibilidade provocada pelo clareamento dentário
Introduction: Reducing in-office tooth bleaching sensitivity represents a challenge for professionals. Researchers have associated the block of the pain receptor TRPA1 with reducing bleaching sensitivity. However, the chemical affinity of analgesic/antiinflammatory drugs to the TRPA1 needs to be v...
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| Formato: | doctoralThesis |
| Idioma: | pt_BR |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/49191 |
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| Resumo: | Introduction: Reducing in-office tooth bleaching sensitivity represents a challenge for
professionals. Researchers have associated the block of the pain receptor TRPA1 with
reducing bleaching sensitivity. However, the chemical affinity of analgesic/antiinflammatory drugs to the TRPA1 needs to be verified. Objective: To perform a virtual
screening of multiple drugs (analgesic and anti-inflammatory drugs) to verify chemical
affinity for the TRPA1 receptor. Methodology: The crystal structure of the TRPA1
receptor proteins was retrieved from the Protein Data Bank. The SMILES codes of the
ligands were extracted from PubChem. The binding energy of the complex was obtained
in ∆G - kcal/mol by AutoDock Vina© and replicated in the webservers SwissDock©,
Dockthor©, and CbDock©. LigPlus© confirmed the binding sites. Results: Although the
receptor antagonists analyzed showed high affinity, codeine and dexamethasone showed
regularity among all servers, even showing binding energy values of -7.9 kcal/mol for
codeine and -8.1 kcal/mol for dexamethasone. Conclusion: Codeine and dexamethasone
may be potential drugs to manage tooth bleaching sensitivity if they reach the dental pulp TRPA1 receptor. |
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