Body composition of duchenne muscular dystrophy patients supplemented with zinc: a clinical trial
Duchenne muscular dystrophy (DMD) is a neuromuscular disease characterized by progressive muscle weakness. The increase in total fat mass and reduction in lean mass are side effects of the disease. The methods for assessing the nutritional status of boys with DMD can be imprecise, and the techniq...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/48338 |
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| Resumo: | Duchenne muscular dystrophy (DMD) is a neuromuscular disease characterized by
progressive muscle weakness. The increase in total fat mass and reduction in lean
mass are side effects of the disease. The methods for assessing the nutritional status
of boys with DMD can be imprecise, and the techniques applied to the general
population are inadequate and difficult to interpret due to their altered body
composition. Zinc is an essential mineral for the synthesis of lean mass. Data on zinc
content in adipose tissue in obesity are still limited. Zinc supplementation affects body
composition, however, this increase occurs especially in children with pre-existing
stunting. To date, there are no studies that assess body composition in boys with DMD
before and after zinc supplementation. Therefore, three studies were carried out. Study
1 was descriptive and cross-sectional, evaluating 49 boys through anthropometric and
body composition parameters. For Study 2, an integrative review was carried out on
zinc and body composition to understand what the literature had on the subject. Study
3 composed a clinical trial that evaluated dietary, biochemical, and body composition
parameters before and after zinc supplementation in 21 boys with DMD. We observed
an increase in fat mass and a decrease in lean mass with age/disease progression.
Zinc supplementation in the population of this study was not enough to increase lean
mass, but it was possible to observe the maintenance of lean and fat mass in those
boys with previous serum zinc deficiency. |
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