Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation

Theta is one of the most prominent extracellular synchronous oscillations in the mammalian brain. Hippocampal theta relies on an intact medial septum (MS) and has been consistently recorded during the training phase of some learning paradigms, suggesting that it may be implicated in hippocampus-depe...

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Principais autores: Gonzalez, Maria Carolina, Radiske, Andressa, Rossato, Janine, Conde-Ocazionez, Sergio, Bevilaqua, Lia Rejane Muller, Cammarota, Martin Pablo
Formato: article
Idioma:English
Publicado em: Springer Science and Business Media LLC
Assuntos:
Theta rhythm
Amnesia
Hippocampus
Brain oscillations
Long-term memor
Endereço do item:https://repositorio.ufrn.br/handle/123456789/48274
https://doi.org/10.1186/s13041-022-00938-3
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spelling ri-123456789-482742022-06-24T13:05:47Z Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation Gonzalez, Maria Carolina Radiske, Andressa Rossato, Janine Conde-Ocazionez, Sergio Bevilaqua, Lia Rejane Muller Cammarota, Martin Pablo Theta rhythm Amnesia Hippocampus Brain oscillations Long-term memor Theta is one of the most prominent extracellular synchronous oscillations in the mammalian brain. Hippocampal theta relies on an intact medial septum (MS) and has been consistently recorded during the training phase of some learning paradigms, suggesting that it may be implicated in hippocampus-dependent long-term memory processing. Object recognition memory (ORM) allows animals to identify familiar items and is essential for remembering facts and events. In rodents, long-term ORM formation requires a functional hippocampus but the involvement of the MS in this process remains controversial. We found that training adult male Wistar rats in a long-term ORM-inducing learning task involving exposure to two different, but behaviorally equivalent novel stimuli objects increased hippocampal theta power, and that suppressing theta via optogenetic MS inactivation caused amnesia. Importantly, the amnesia was specific to the object the animals were exploring when the MS was inactivated. Taken together, our results indicate that the MS is necessary for long-term ORM formation and suggest that hippocampal theta activity is causally linked to this process 2022-06-24T13:05:46Z 2022-06-24T13:05:46Z 2022-06-07 article GONZALEZ, Maria Carolina; RADISKE, Andressa; ROSSATO, Janine; CONDE-OCAZIONEZ, Sergio; BEVILAQUA, Lia R. M.; CAMMAROTA, Martin. Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation. Molecular Brain, Reino Unido, v. 15, n. 50, jun. 2022. Doi: https://doi.org/10.1186/s13041-022-00938-3. Disponível em: https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-022-00938-3. Acesso em: 23 jun. 2022. https://repositorio.ufrn.br/handle/123456789/48274 https://doi.org/10.1186/s13041-022-00938-3 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Springer Science and Business Media LLC
institution Repositório Institucional
collection RI - UFRN
language English
topic Theta rhythm
Amnesia
Hippocampus
Brain oscillations
Long-term memor
spellingShingle Theta rhythm
Amnesia
Hippocampus
Brain oscillations
Long-term memor
Gonzalez, Maria Carolina
Radiske, Andressa
Rossato, Janine
Conde-Ocazionez, Sergio
Bevilaqua, Lia Rejane Muller
Cammarota, Martin Pablo
Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation
description Theta is one of the most prominent extracellular synchronous oscillations in the mammalian brain. Hippocampal theta relies on an intact medial septum (MS) and has been consistently recorded during the training phase of some learning paradigms, suggesting that it may be implicated in hippocampus-dependent long-term memory processing. Object recognition memory (ORM) allows animals to identify familiar items and is essential for remembering facts and events. In rodents, long-term ORM formation requires a functional hippocampus but the involvement of the MS in this process remains controversial. We found that training adult male Wistar rats in a long-term ORM-inducing learning task involving exposure to two different, but behaviorally equivalent novel stimuli objects increased hippocampal theta power, and that suppressing theta via optogenetic MS inactivation caused amnesia. Importantly, the amnesia was specific to the object the animals were exploring when the MS was inactivated. Taken together, our results indicate that the MS is necessary for long-term ORM formation and suggest that hippocampal theta activity is causally linked to this process
format article
author Gonzalez, Maria Carolina
Radiske, Andressa
Rossato, Janine
Conde-Ocazionez, Sergio
Bevilaqua, Lia Rejane Muller
Cammarota, Martin Pablo
author_facet Gonzalez, Maria Carolina
Radiske, Andressa
Rossato, Janine
Conde-Ocazionez, Sergio
Bevilaqua, Lia Rejane Muller
Cammarota, Martin Pablo
author_sort Gonzalez, Maria Carolina
title Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation
title_short Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation
title_full Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation
title_fullStr Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation
title_full_unstemmed Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation
title_sort optogenetic inactivation of the medial septum impairs long-term object recognition memory formation
publisher Springer Science and Business Media LLC
publishDate 2022
url https://repositorio.ufrn.br/handle/123456789/48274
https://doi.org/10.1186/s13041-022-00938-3
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AT rossatojanine optogeneticinactivationofthemedialseptumimpairslongtermobjectrecognitionmemoryformation
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AT bevilaqualiarejanemuller optogeneticinactivationofthemedialseptumimpairslongtermobjectrecognitionmemoryformation
AT cammarotamartinpablo optogeneticinactivationofthemedialseptumimpairslongtermobjectrecognitionmemoryformation
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