Os papéis da piroptose e da NETose na progessão da Covid-19 grave: Uma revisão de literatura
Covid-19 emerged at the end of 2019, caused by a virus from the Coronavirus family, called SARS-CoV-2. Until January, 2022, more than 393 million people worldwide have been infected and more than 5.7 million people have died. Covid-19 has a diverse/variable symptomatology, ranging from asymptomatic...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/47547 |
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| Resumo: | Covid-19 emerged at the end of 2019, caused by a virus from the Coronavirus family, called SARS-CoV-2. Until January, 2022, more than 393 million people worldwide have been infected and more than 5.7 million people have died. Covid-19 has a diverse/variable symptomatology, ranging from asymptomatic infection to mild, moderate or severe manifestations. The severe form of Covid-19 is characterized by an intense pulmonary inflammatory process, causing Acute Respiratory Distress Syndrome (ARDS), which can progress to Systemic Inflammatory Response Syndrome (SIRS). This serious evolution is due to the development of a cytokine storm that, associated with immunothrombosis events, contributes to coagulopathy in response to the lack of control in the activation of immune system cells. Some of the main events related to a fatal outcome in SARS-CoV-2 infection are the intense activation of an enzyme complex called NLRP3 inflammasome within infected cells. Its activation culminates in the robust release of pro-inflammatory cytokines, such as IL-1β and IL-18, through a death process called pyroptosis, as well as other cytokines, such as IL-2, IL-6, TNF-α, IFN-γ and chemokines, a consequence of cellular activation. These events lead to massive recruitment of leukocytes in the lung, with intense neutrophilic infiltrate and the formation of extracellular neutrophil traps (NETs), which have a direct role in lung damage and coagulopathy in patients with the severe form of the disease. Given the importance of the various events involved in the pathogenesis of Covid-19, in this study, an literature review was performed in order to gather the most up-to-date information on the role of pyroptosis and NETosis in the severe progression of patients with Covid-19. |
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