Obtenção e desenvolvimento de biofilmes de PHB visando aplicação em tratamento de queimaduras
Making the treatment of burn patients more effective is beneficial for both the patient and the multidisciplinary team and institution. Thereby, I consider new and more effective technologies for the treatment of this type of injury, among which the development of materials for biomedical applicatio...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/47484 |
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| Resumo: | Making the treatment of burn patients more effective is beneficial for both the patient and the multidisciplinary team and institution. Thereby, I consider new and more effective technologies for the treatment of this type of injury, among which the development of materials for biomedical applications stands out. In this segment, I utilitze biopolymers as matrices for drug delivery systems (DDSs), highlighting the use of polyhydroxybutyrate (PHB) as a polymeric matrix. PHB is a polymer of the class of polyhydroxyalkanoates, has a thermoplastic behavior, is semi-crystalline (60-80%), has a high melting point, and is biocompatible and biodegradable, the latter ones considered fundamental characteristics for the success of biomaterials. Burns are extremely damaging injuries to tissues, because in addition to destroying the natural barrier, the skin, they provide the opportunity for the invasion of infectious agents, which is the major cause of deaths from burns. With that in mind, I chose to use silver sulfate (Ag2SO4) as an active component of biofilms due to its antibacterial characteristics. Thus, my work proposes the development of biofilms in order to cover burn injuries by offering a mechanical barrier, an appropriate environment for tissue regeneration and antibacterial action. For this purpose, PHB/Ag2SO4 membranes were developed in different proportions by applying the phase inversion method and the vapor-induced phase separation process. The films produced were characterized by X-Ray Diffraction (XRD), Fourier-Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscope (SEM). Using the XRD analysis, I examined the increase in the amorphous region of biofilms after the incorporation of Ag2SO4. With the FTIR, I verified that the PHB characteristic organic groups were preserved during the processing steps, maintaining their biological properties. The SEM analysis demonstrated that the dense PHB structure became porous from the incorporation of Ag2SO4, obtaining better results for samples with lower load concentrations. Data indicated that the addition of Ag2SO4 to the PHB improves the physical properties of the biofilm, allowing further studies to be carried out for possible use in tissue engineering. |
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