Avaliação do ângulo de fase padronizado como preditor de eventos cardiovasculares adversos de curto e longo prazo em pacientes com infarto agudo do miocárdio: um estudo de coorte
Cardiovascular diseases (CVDs) underscore themselves as the main cause of death in the world, and this includes coronary diseases. Amongst coronary diseases, the acute myocardial infarction (AMI) is defined as myocardial necrosis in a consistent clinical condition with myocardial ischemia. It is...
Na minha lista:
| Autor principal: | |
|---|---|
| Outros Autores: | |
| Formato: | Dissertação |
| Idioma: | pt_BR |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
|
| Assuntos: | |
| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/47165 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
| Resumo: | Cardiovascular diseases (CVDs) underscore themselves as the main cause of
death in the world, and this includes coronary diseases. Amongst coronary
diseases, the acute myocardial infarction (AMI) is defined as myocardial
necrosis in a consistent clinical condition with myocardial ischemia. It is an
acute cardiac event with an impact on the health condition, and its risk factors
are usually a combination of the use of tobacco, inadequate diet, obesity, and
sedentary lifestyle, besides to pre-existing comorbidities. These risk factors can
compromise the cellular integrity impacting on physiological and nutritional
components. In this approach, the phase angle (PA) has measured by
bioelectrical impedance (BIA) and identifies the quality of the cell membrane
and the distribution of body fluids. There are previous evidences that, this
biomarker has a high negative predictive power of clinical outcomes, such as
mortality and hospital readmission in several clinical situations. Therefore, this
study aimed to verify if the standardized PhA (SPhA) is a predictor of short and
long-term adverse cardiovascular events in patients who were recently affected
by AMI. Therefore, our work aims to check if the PA is predictor of mortality and
adverse clinical events in 12 months of patients who were recently affected by
AMI. It was done a 12-month prospective cohort study. Furthermore, it was
included adults and elderly patients with both sexes who were admitted to the
University Hospital Onofre Lopes (UHOL/FURN) with a diagnosis of AMI. The
patients were evaluated during hospitalization, and it was collected
demographic, clinical, and nutritional data. Body weight, height, and calf
circumference was measured using the anthropometric technique. Handgrip
strength was measured with a manual dynamometer. The PA was calculated
through the measuring of the resistance (R) and reactance (Xc) of the BIA, and
it was adjusted based on sex and age, presenting, therefore, the standardized
PA (SPhA). Major adverse cardiac events (MACE) were observed during follow-
up and among them, new hospital admission for unstable angina, new
myocardial infarction and cardiovascular mortality were included in the
analyses. All patients were followed for 12 months. The sample consisted of
153 patients, with a mean age of 61.2 ± 12.6 years, being 57.5% elderly.
Patients who presented the standardized phase angle below the 10th percentile had a shorter time for the occurrence of death (p=0.024). In the univariate
analysis, mortality was shown as a significant outcome (p= 0.036), but the other
outcomes did not show an association in the Cox regression when adjusted for
the confounding factor. In conclusion, patients recently affected by AMI and who
had low SPhA had a higher incidence of mortality at 12 months. However, when
adjusted for cardiovascular risk factors, we found no association between SPhA
and MACE and mortality. |
|---|