Associação da imunoexpressão da e-caderina com as características clinicopatológicas do carcinoma epidermoide de língua oral
Oral squamous cell carcinoma (OSCC) represents approximately 90% of oral cancer cases, being the tongue the most affected site. cadherin-E is one of the main agents involved in the epithelial-mesenchymal transition (EMT) process, a crucial event for tumor invasion and metastasis. Therefore, the pres...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/46154 |
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| Resumo: | Oral squamous cell carcinoma (OSCC) represents approximately 90% of oral cancer cases, being the tongue the most affected site. cadherin-E is one of the main agents involved in the epithelial-mesenchymal transition (EMT) process, a crucial event for tumor invasion and metastasis. Therefore, the present study aims to investigate the immunoexpression of the cadherin-E protein in oral tongue squamous cell carcinoma (OTSCC) and its association with clinical and morphological prognostic parameters of this lesion. This is a descriptive, cross-sectional and retrospective study of OTSCC cases, as well as a descriptive analysis of the immunoexpression of cadherin-E in these lesions. OTSCC in lingual site cases were collected in Pathological Anatomy Service at the UFRN’s Dentistry Department, where 41 cases and it’s clinical information were selected. After that, descriptive analysis where done and association were evaluated between the variables and OTSCC gradation using statistical tests, Pearson’s Qui-Squari and Fisher Exact. It was revealed that tumors treated with combination therapies due to advanced clinical staging at diagnosis tend to have high expression of cytoplasmic Cadherin-E on the invasion front, as well as low membrane Cadherin-E expression on the tumor invasion front. indicative of worse prognosis and overall survival at 5 years.The results of the study indicate that E- cadherin represents a potential biomarker of tumor aggressiveness in OTSCC |
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