Análise morfológica do canibalismo celular em lesões de células gigantes
Introduction: Peripheral giant cell granulomas (PGCG), central giant cell granulomas (CGCG), and giant cell tumor (GCT) of bone are lesions that show histopathological similarities, but very different biological behaviors. Cellular cannibalism, common in aggressive malignant neoplasms, has been ass...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/45816 |
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| Resumo: | Introduction: Peripheral giant cell granulomas (PGCG), central giant cell granulomas (CGCG), and giant cell tumor (GCT) of bone are lesions that show histopathological similarities, but very different biological behaviors. Cellular cannibalism, common in aggressive malignant neoplasms,
has been associated with biological behavior in some giant cell lesions. Objective: To Evaluate and compare the presence of cellular cannibalism in PGCG, CGCG and GCT. Methods: This was a retrospective and quantitative study with 42 cases of PGCGs, 43 cases of CGCGs (24 aggressive and 19 non-aggressive), and 16 cases of GCTs morphologically analyzed on slides stained with hematoxylin and eosin (H/E). Cannibal Cells (CCs) were counted on slides scanned among 100 Multinucleated Giant Cells (MGCs) in these lesions. Results: CCs were identified in 33 cases of PGCGs (78.5%), 4 cases of non-aggressive CGCGs (16.6%), 13 cases of aggressive CGCGs (68.4%), and 16 cases of GCTs of bone (88.9%). The presence of CCs was higher in PGCGs, when compared to aggressive (n = 19, 45%) and nonaggressive (n = 19, 45%) CGCGs, with statistical significance for both (p ≤ 0.0001 and p ≤ 0.05, respectively). In addition, non-aggressive CGCGs exhibited a lower number of canibal multinucleated giant cells when compared to aggressive CGCGs and GCTs of bone (p ≤ 0.001 and p ≤ 0.0001, respectively). Conclusion: The higher frequency of CCs in PGCGs suggests that these cells participate in the pathogenesis of this lesion and, additionally, the lower number of these cells in non-aggressive GCGC, when compared to aggressive ones and GCTs of bone, partially explains the difference in biological behavior between these lesions. |
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