Avoidance memory requires CaMKII activity to persist after recall

Avoidance memory is destabilized when recalled concurrently with conficting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement...

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Principais autores: Radiske, Andressa, Gonzalez, Maria Carolina, Rossato, Janine Inez, Apolinário, Gênedy Karielly da Silva, Oliveira, João R. de, Bevilaqua, Lia Rejane Müller, Cammarota, Martín Pablo
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Idioma:English
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Assuntos:
Reconsolidation
PTSD
Fear
Hippocampus
Retrieval
Endereço do item:https://repositorio.ufrn.br/handle/123456789/45699
https://doi.org/10.1186/s13041-021-00877-5
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spelling ri-123456789-456992022-01-20T12:45:00Z Avoidance memory requires CaMKII activity to persist after recall Radiske, Andressa Gonzalez, Maria Carolina Rossato, Janine Inez Apolinário, Gênedy Karielly da Silva Oliveira, João R. de Bevilaqua, Lia Rejane Müller Cammarota, Martín Pablo Reconsolidation PTSD Fear Hippocampus Retrieval Avoidance memory is destabilized when recalled concurrently with conficting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses 2022-01-20T12:44:59Z 2022-01-20T12:44:59Z 2021-11-14 article RADISKE, Andressa; GONZALEZ, Maria Carolina; ROSSATO, Janine Inez; APOLINÁRIO, Gênedy; OLIVEIRA, João R. de; BEVILAQUA, Lia Rejane Müller; CAMMAROTA, Martín Pablo. Avoidance memory requires CaMKII activity to persist after recall. Molecular Brain, [S. l.], v. 14, p. 167, nov. 2021. Doi: 10.1186/s13041-021-00877-5. Disponível em: https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00877-5. Acesso em: 20 jan. 2022. https://repositorio.ufrn.br/handle/123456789/45699 https://doi.org/10.1186/s13041-021-00877-5 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf
institution Repositório Institucional
collection RI - UFRN
language English
topic Reconsolidation
PTSD
Fear
Hippocampus
Retrieval
spellingShingle Reconsolidation
PTSD
Fear
Hippocampus
Retrieval
Radiske, Andressa
Gonzalez, Maria Carolina
Rossato, Janine Inez
Apolinário, Gênedy Karielly da Silva
Oliveira, João R. de
Bevilaqua, Lia Rejane Müller
Cammarota, Martín Pablo
Avoidance memory requires CaMKII activity to persist after recall
description Avoidance memory is destabilized when recalled concurrently with conficting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses
format article
author Radiske, Andressa
Gonzalez, Maria Carolina
Rossato, Janine Inez
Apolinário, Gênedy Karielly da Silva
Oliveira, João R. de
Bevilaqua, Lia Rejane Müller
Cammarota, Martín Pablo
author_facet Radiske, Andressa
Gonzalez, Maria Carolina
Rossato, Janine Inez
Apolinário, Gênedy Karielly da Silva
Oliveira, João R. de
Bevilaqua, Lia Rejane Müller
Cammarota, Martín Pablo
author_sort Radiske, Andressa
title Avoidance memory requires CaMKII activity to persist after recall
title_short Avoidance memory requires CaMKII activity to persist after recall
title_full Avoidance memory requires CaMKII activity to persist after recall
title_fullStr Avoidance memory requires CaMKII activity to persist after recall
title_full_unstemmed Avoidance memory requires CaMKII activity to persist after recall
title_sort avoidance memory requires camkii activity to persist after recall
publishDate 2022
url https://repositorio.ufrn.br/handle/123456789/45699
https://doi.org/10.1186/s13041-021-00877-5
work_keys_str_mv AT radiskeandressa avoidancememoryrequirescamkiiactivitytopersistafterrecall
AT gonzalezmariacarolina avoidancememoryrequirescamkiiactivitytopersistafterrecall
AT rossatojanineinez avoidancememoryrequirescamkiiactivitytopersistafterrecall
AT apolinariogenedykariellydasilva avoidancememoryrequirescamkiiactivitytopersistafterrecall
AT oliveirajoaorde avoidancememoryrequirescamkiiactivitytopersistafterrecall
AT bevilaqualiarejanemuller avoidancememoryrequirescamkiiactivitytopersistafterrecall
AT cammarotamartinpablo avoidancememoryrequirescamkiiactivitytopersistafterrecall
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