Case report: combination therapy with liposomal amphotericin B, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient

In immunocompromised patients, visceral leishmaniasis (VL) can present with atypical clinical symptoms that include poorresponse to treatment.Nooptimal therapeuticregimen is available for such cases. In a splenectomizedmale patient, we observed a disseminated form of the disease in the liver, bone...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Vechi, Hareton Teixeira, Sousa, Ana Solange Vasconcelos de, Cunha, Mirella Alves da, Shaw, Jeffrey Jon, Luz, Kleber Giovanni
Formato: article
Idioma:English
Publicado em: American Society of Tropical Medicine and Hygiene
Assuntos:
Visceral leishmaniasis
Splenectomized Adult Patient
Endereço do item:https://repositorio.ufrn.br/handle/123456789/45639
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id ri-123456789-45639
record_format dspace
spelling ri-123456789-456392022-01-17T16:25:09Z Case report: combination therapy with liposomal amphotericin B, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient Vechi, Hareton Teixeira Sousa, Ana Solange Vasconcelos de Cunha, Mirella Alves da Shaw, Jeffrey Jon Luz, Kleber Giovanni Visceral leishmaniasis Splenectomized Adult Patient In immunocompromised patients, visceral leishmaniasis (VL) can present with atypical clinical symptoms that include poorresponse to treatment.Nooptimal therapeuticregimen is available for such cases. In a splenectomizedmale patient, we observed a disseminated form of the disease in the liver, bone marrow, lymph nodes, and gastrointestinal tract. Therewas an apparent clinical improvementwhenhewas initiallytreatedwith liposomal amphotericin B (L-AmB), butthiswas followed by a relapse involving severe clinical symptoms. He was finally treated successfully with a combination of L-AmB, meglumine antimoniate, and pentamidine isethionate. It is important to include asplenia as an immunosuppressive condition that induces exotic VL pathologies. In such cases, combination anti-Leishmania drug therapy should be considered 2022-01-17T16:25:08Z 2022-01-17T16:25:08Z 2020-02-05 article VECHI, Hareton Teixeira et al. Case Report: combination therapy with liposomal amphotericin b, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient. The American Journal Of Tropical Medicine And Hygiene, [s. l.], v. 102, n. 2, p. 268-273, 5 fev. 2020. American Society of Tropical Medicine and Hygiene. http://dx.doi.org/10.4269/ajtmh.18-0999. Disponível em: http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0999. Acesso em: 16 out. 2020. 0002-9637 (print) https://repositorio.ufrn.br/handle/123456789/45639 10.4269/ajtmh.18-0999 en application/pdf American Society of Tropical Medicine and Hygiene
institution Repositório Institucional
collection RI - UFRN
language English
topic Visceral leishmaniasis
Splenectomized Adult Patient
spellingShingle Visceral leishmaniasis
Splenectomized Adult Patient
Vechi, Hareton Teixeira
Sousa, Ana Solange Vasconcelos de
Cunha, Mirella Alves da
Shaw, Jeffrey Jon
Luz, Kleber Giovanni
Case report: combination therapy with liposomal amphotericin B, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient
description In immunocompromised patients, visceral leishmaniasis (VL) can present with atypical clinical symptoms that include poorresponse to treatment.Nooptimal therapeuticregimen is available for such cases. In a splenectomizedmale patient, we observed a disseminated form of the disease in the liver, bone marrow, lymph nodes, and gastrointestinal tract. Therewas an apparent clinical improvementwhenhewas initiallytreatedwith liposomal amphotericin B (L-AmB), butthiswas followed by a relapse involving severe clinical symptoms. He was finally treated successfully with a combination of L-AmB, meglumine antimoniate, and pentamidine isethionate. It is important to include asplenia as an immunosuppressive condition that induces exotic VL pathologies. In such cases, combination anti-Leishmania drug therapy should be considered
format article
author Vechi, Hareton Teixeira
Sousa, Ana Solange Vasconcelos de
Cunha, Mirella Alves da
Shaw, Jeffrey Jon
Luz, Kleber Giovanni
author_facet Vechi, Hareton Teixeira
Sousa, Ana Solange Vasconcelos de
Cunha, Mirella Alves da
Shaw, Jeffrey Jon
Luz, Kleber Giovanni
author_sort Vechi, Hareton Teixeira
title Case report: combination therapy with liposomal amphotericin B, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient
title_short Case report: combination therapy with liposomal amphotericin B, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient
title_full Case report: combination therapy with liposomal amphotericin B, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient
title_fullStr Case report: combination therapy with liposomal amphotericin B, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient
title_full_unstemmed Case report: combination therapy with liposomal amphotericin B, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient
title_sort case report: combination therapy with liposomal amphotericin b, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient
publisher American Society of Tropical Medicine and Hygiene
publishDate 2022
url https://repositorio.ufrn.br/handle/123456789/45639
work_keys_str_mv AT vechiharetonteixeira casereportcombinationtherapywithliposomalamphotericinbnmethylmeglumineantimoniateandpentamidineisethionatefordisseminatedvisceralleishmaniasisinasplenectomizedadultpatient
AT sousaanasolangevasconcelosde casereportcombinationtherapywithliposomalamphotericinbnmethylmeglumineantimoniateandpentamidineisethionatefordisseminatedvisceralleishmaniasisinasplenectomizedadultpatient
AT cunhamirellaalvesda casereportcombinationtherapywithliposomalamphotericinbnmethylmeglumineantimoniateandpentamidineisethionatefordisseminatedvisceralleishmaniasisinasplenectomizedadultpatient
AT shawjeffreyjon casereportcombinationtherapywithliposomalamphotericinbnmethylmeglumineantimoniateandpentamidineisethionatefordisseminatedvisceralleishmaniasisinasplenectomizedadultpatient
AT luzklebergiovanni casereportcombinationtherapywithliposomalamphotericinbnmethylmeglumineantimoniateandpentamidineisethionatefordisseminatedvisceralleishmaniasisinasplenectomizedadultpatient
_version_ 1773957655889444864

Registros relacionados