Propriedades anti-inflamatórias e antioxidantes de blends do suco de Malpighia emarginata D. C. (acerola) e infusão de Camellia sinensis L. (chá verde)
Medicinal plants have been studied for centuries for their medicinal properties, including Malpighia emarginata D. C. (acerola) and Camellia sinensis L. (green tea) has been an alternative preventive and medicinal approach for various pathologies. In view of the potential anti-inflammatory and antio...
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| Formato: | doctoralThesis |
| Idioma: | pt_BR |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/45491 |
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| Resumo: | Medicinal plants have been studied for centuries for their medicinal
properties, including Malpighia emarginata D. C. (acerola) and Camellia sinensis L.
(green tea) has been an alternative preventive and medicinal approach for various
pathologies. In view of the potential anti-inflammatory and antioxidant uses, in this work
we developed a mixture formulated in powder with Malpighia emarginata D. C. and
Camellia sinensis L. which have a higher content of ascorbic acid and
epigallatecatechin-3-gallate, respectively. The production of the blend was carried out
through the spray drying process, using microencapsulation methods. Subsequently,
the antioxidant and anti-inflammatory properties of the formulated blends were
evaluated in an in vitro inflammatory model, using the RAW-264.7 macrophage cell
line in two treatments, cells against extract and co-treatment, which are the blends
against stimulated cells by lipopolysaccharide. We observed that co-treatment with
blends was able to modulate redox parameters in cells during the in vitro inflammatory
response. Furthermore, the co-treatment with the blends was able to modulate the
inflammatory response, altering the secretion of IL-1β, IL-6, IL-10 and TNF-α cytokines.
Thus, our results observed together demonstrate for the first time the synergistic
antioxidant and anti-inflammatory effects of Malpighia emarginata D. C. and Camellia
sinensis L. Thus justifying the additional use of this mixture in products that may bring
health benefits, especially in terms of prevention of chronic diseases. |
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