Avaliação toxicológica e mutagênica do extrato aquoso das folhas de Licania rigida Benth em associação aos seus efeitos protetores sobre o estresse oxidativo
Medicinal plants present bioactive substances that help in the treatment of the most diverse diseases and their use for therapeutic purposes is as old as human civilization. In Brazil, the use of medicinal plants for primary health care is widespread due to its large plant biodiversity, low cost, ea...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/45142 |
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| Resumo: | Medicinal plants present bioactive substances that help in the treatment of the most
diverse diseases and their use for therapeutic purposes is as old as human civilization.
In Brazil, the use of medicinal plants for primary health care is widespread due to its
large plant biodiversity, low cost, easy access, and wide popular knowledge about their
use. However, it is worth noting that most species used in traditional medicine do not
present scientific studies proving their efficacy, safety, chemical composition, or
possible toxicity. In this context, the species Licania rigida Benth belonging to the
Chrysobalanaceae family is a plant species found in the semiarid northeastern Brazil,
being used in folk medicine for the treatment of inflammatory processes and diabetes.
However, despite its use, there are few studies to validate its pharmacological and
toxicological potential. As a result, the objective of this study was to evaluate the
toxicological properties of the aqueous extract of Licania rigida through standardized
methods of acute and subchronic oral toxicity, mutagenicity and cytotoxicity, as well as
its possible protective effect against oxidative stress. The extract did not show any toxic
or genotoxic effect in the in vivo and in vitro assays after exposure to different
concentrations. With regard to the antioxidant effect, the extract exhibited a possible
protective effect by decreasing the level of malondialdehyde (MDA) in treated animals;
no significant changes were observed for reduced glutathione (GSH), superoxide
dismutase (SOD) and glutathione peroxidase (GPX) levels. Therefore, it is proposed
that Licania rigida leaf extract may become a future herbal medicine, however, further
studies are needed to validate its pharmacological application and for the development
of new herbal formulations. |
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