Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders

The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in executive and emotional functions. Neurophysiological studies have begun to unveil the dynamics of HPC-PFC interaction in both immediate demands and longterm adaptations. Disruptions in HPC-PFC functional connectivity ca...

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Principais autores: Ruggiero, Rafael Naime, Rossignoli, Matheus Teixeira, Marques, Danilo Benette, Sousa, Bruno Monteiro de, Romcy-Pereira, Rodrigo Neves, Lopes-Aguiar, Cleiton, Leite, João Pereira
Formato: article
Idioma:English
Publicado em: Frontiers In Cellular Neuroscience
Assuntos:
Hippocampus
Prefrontal cortex
Long-term potentiation (LTP)
Long-term depression (LTD)
Local field potential (LFP)
Acetylcholine
Monoamines
Cannabinoids
Endereço do item:https://repositorio.ufrn.br/handle/123456789/45095
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spelling ri-123456789-450952021-11-30T14:15:57Z Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders Ruggiero, Rafael Naime Rossignoli, Matheus Teixeira Marques, Danilo Benette Sousa, Bruno Monteiro de Romcy-Pereira, Rodrigo Neves Lopes-Aguiar, Cleiton Leite, João Pereira Hippocampus Prefrontal cortex Long-term potentiation (LTP) Long-term depression (LTD) Local field potential (LFP) Acetylcholine Monoamines Cannabinoids The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in executive and emotional functions. Neurophysiological studies have begun to unveil the dynamics of HPC-PFC interaction in both immediate demands and longterm adaptations. Disruptions in HPC-PFC functional connectivity can contribute to neuropsychiatric symptoms observed in mental illnesses and neurological conditions, such as schizophrenia, depression, anxiety disorders, and Alzheimer’s disease. Given the role in functional and dysfunctional physiology, it is crucial to understand the mechanisms that modulate the dynamics of HPC-PFC communication. Two of the main mechanisms that regulate HPC-PFC interactions are synaptic plasticity and modulatory neurotransmission. Synaptic plasticity can be investigated inducing longterm potentiation or long-term depression, while spontaneous functional connectivity can be inferred by statistical dependencies between the local field potentials of both regions. In turn, several neurotransmitters, such as acetylcholine, dopamine, serotonin, noradrenaline, and endocannabinoids, can regulate the fine-tuning of HPC-PFC connectivity. Despite experimental evidence, the effects of neuromodulation on HPCPFC neuronal dynamics from cellular to behavioral levels are not fully understood. The current literature lacks a review that focuses on the main neurotransmitter interactions with HPC-PFC activity. Here we reviewed studies showing the effects of the main neurotransmitter systems in long- and short-term HPC-PFC synaptic plasticity. We also looked for the neuromodulatory effects on HPC-PFC oscillatory coordination. Finally, we review the implications of HPC-PFC disruption in synaptic plasticity and functional connectivity on cognition and neuropsychiatric disorders. The comprehensive overview of these impairments could help better understand the role of neuromodulation in HPC-PFC communication and generate insights into the etiology and physiopathology of clinical conditions 2021-11-30T14:15:57Z 2021-11-30T14:15:57Z 2021-10-11 article RUGGIERO, Rafael Naime; ROSSIGNOLI, Matheus Teixeira; MARQUES, Danilo Benette; SOUSA, Bruno Monteiro de; ROMCY-PEREIRA, Rodrigo Neves; LOPES-AGUIAR, Cleiton; LEITE, João Pereira. Neuromodulation of Hippocampal-Prefrontal Cortical Synaptic Plasticity and Functional Connectivity: implications for neuropsychiatric disorders. Frontiers In Cellular Neuroscience, [S. l.], v. 15, p. 1-23, 11 out. 2021. DOI: https://doi.org/10.3389/fncel.2021.732360 https://repositorio.ufrn.br/handle/123456789/45095 10.3389/fncel.2021.732360 en Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Frontiers In Cellular Neuroscience
institution Repositório Institucional
collection RI - UFRN
language English
topic Hippocampus
Prefrontal cortex
Long-term potentiation (LTP)
Long-term depression (LTD)
Local field potential (LFP)
Acetylcholine
Monoamines
Cannabinoids
spellingShingle Hippocampus
Prefrontal cortex
Long-term potentiation (LTP)
Long-term depression (LTD)
Local field potential (LFP)
Acetylcholine
Monoamines
Cannabinoids
Ruggiero, Rafael Naime
Rossignoli, Matheus Teixeira
Marques, Danilo Benette
Sousa, Bruno Monteiro de
Romcy-Pereira, Rodrigo Neves
Lopes-Aguiar, Cleiton
Leite, João Pereira
Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders
description The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in executive and emotional functions. Neurophysiological studies have begun to unveil the dynamics of HPC-PFC interaction in both immediate demands and longterm adaptations. Disruptions in HPC-PFC functional connectivity can contribute to neuropsychiatric symptoms observed in mental illnesses and neurological conditions, such as schizophrenia, depression, anxiety disorders, and Alzheimer’s disease. Given the role in functional and dysfunctional physiology, it is crucial to understand the mechanisms that modulate the dynamics of HPC-PFC communication. Two of the main mechanisms that regulate HPC-PFC interactions are synaptic plasticity and modulatory neurotransmission. Synaptic plasticity can be investigated inducing longterm potentiation or long-term depression, while spontaneous functional connectivity can be inferred by statistical dependencies between the local field potentials of both regions. In turn, several neurotransmitters, such as acetylcholine, dopamine, serotonin, noradrenaline, and endocannabinoids, can regulate the fine-tuning of HPC-PFC connectivity. Despite experimental evidence, the effects of neuromodulation on HPCPFC neuronal dynamics from cellular to behavioral levels are not fully understood. The current literature lacks a review that focuses on the main neurotransmitter interactions with HPC-PFC activity. Here we reviewed studies showing the effects of the main neurotransmitter systems in long- and short-term HPC-PFC synaptic plasticity. We also looked for the neuromodulatory effects on HPC-PFC oscillatory coordination. Finally, we review the implications of HPC-PFC disruption in synaptic plasticity and functional connectivity on cognition and neuropsychiatric disorders. The comprehensive overview of these impairments could help better understand the role of neuromodulation in HPC-PFC communication and generate insights into the etiology and physiopathology of clinical conditions
format article
author Ruggiero, Rafael Naime
Rossignoli, Matheus Teixeira
Marques, Danilo Benette
Sousa, Bruno Monteiro de
Romcy-Pereira, Rodrigo Neves
Lopes-Aguiar, Cleiton
Leite, João Pereira
author_facet Ruggiero, Rafael Naime
Rossignoli, Matheus Teixeira
Marques, Danilo Benette
Sousa, Bruno Monteiro de
Romcy-Pereira, Rodrigo Neves
Lopes-Aguiar, Cleiton
Leite, João Pereira
author_sort Ruggiero, Rafael Naime
title Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders
title_short Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders
title_full Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders
title_fullStr Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders
title_full_unstemmed Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders
title_sort neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders
publisher Frontiers In Cellular Neuroscience
publishDate 2021
url https://repositorio.ufrn.br/handle/123456789/45095
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