Micropartículas poliméricas obtidas por spray-drying para liberação de um derivado tiofeno
2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (6CN) is a thiophene derivative with antiproliferative activity against cancer cell lines. However, presents low aqueous solubility which interferes its clinical use. This work aims to evaluate the influence of microencapsulation technique t...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/44816 |
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| Resumo: | 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (6CN) is a thiophene
derivative with antiproliferative activity against cancer cell lines. However,
presents low aqueous solubility which interferes its clinical use. This work aims
to evaluate the influence of microencapsulation technique to developed a new
system capable of modulate its release. 6CN-loaded hydroxypropyl
methylcellulose (HPMC) microspheres employing the spray-drying method were
developed with different drug-polymer ratios. These systems were characterized
for drug content (%), infrared, scanning electron microscopy (SEM), X-ray
diffraction (XRD), granulometric and differential scanning calorimetry (DSC)
analysis. The systems showed a drug content (%) between 70-80%, although
losses during the developing process. Infrared results evidenced interactions
between the components of the formulation. The granulometric analysis showed
microparticles with an average size between 31-47 µm and SEM analysis showed
particles with a well-defined and smooth spherical surface morphology. XRD and
DSC analysis confirmed the 6CN crystalline nature. In contrast, in the systems it
showed an amorphous state. The kinetics study with the dialysis method showed
that after 10 hours almost 100% of 6CN was released in both medium (pH 1.2
and pH 7.4). The systems MP2 and MP3 were capable of promote a controlled
release for 56 hours fitted the mono and biexponential model. |
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