Efeito do antidepressivo sertralina sobre parâmetros espermáticos e na contração do epidídimo de rato
Sertraline is an antidepressant drug used for the treatment of depressive disorders that are able to diminish male fertility by decreasing the sperm cell numbers in the ejaculate. However, the mechanism related to these effects is still not unknown. Moreover, it is reported that epididymis contracti...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/43222 |
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| Resumo: | Sertraline is an antidepressant drug used for the treatment of depressive disorders that are able to diminish male fertility by decreasing the sperm cell numbers in the ejaculate. However, the mechanism related to these effects is still not unknown. Moreover, it is reported that epididymis contractions could be altered by different drugs, affecting the number of sperm cells and leading to impairment of male fertility. Then, this study aimed to investigate if sertraline could affect the epididymis contraction, altering the sperm transit and/or sperm number in different parts of epididymis. In vitro effects of sertraline (1, 3 and 10 μM) were evaluated in isolated distal cauda epididymis mounted in an organ bath set up. The long-term treatment with sertraline (20 mg.Kg-1,i.p.) for 21 days were also evaluated on distal cauda epididymis contractions, serum testosterone levels and sperm parameters. In vitro sertraline > 3 μM decreased the contractions of distal cauda epididymis induced by KCl, phenylephrine or carbachol. In addition, the long-term in vivo treatment with sertraline promoted an enhancement of distal cauda spontaneous contractions and a potentiation of adrenergic agonist-induced contractions. Thus, we also found that in vivo sertraline treatments decreased the serum testosterone level, diminished daily sperm production, sperm reserves trough epididymis and sperm transit time in cauda epididymis. Altogether, our results indicated that sertraline is able to alter the motor activity of epididymis which could be associated to the low sperm count in this organ and accelerated transit time trough epididymal cauda found in treated animals. |
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