Prevalência do vírus zika no Estado do Rio Grande do Norte no período de 2014 a 2015
Zika virus (ZIKV) is an arbovirus belonging to the Flaviviridae family and genus Flavivirus, and is closely related to yellow fever, dengue, West Nile virus and Japanese encephalitis virus. It was first isolated in Uganda on the African continent in April 1947 in the Zika Forest. In addition to vect...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/43214 |
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| Resumo: | Zika virus (ZIKV) is an arbovirus belonging to the Flaviviridae family and genus Flavivirus, and is closely related to yellow fever, dengue, West Nile virus and Japanese encephalitis virus. It was first isolated in Uganda on the African continent in April 1947 in the Zika Forest. In addition to vector transmission by the bite of infected Aedes mosquitoes, or ZIKV can also be transmitted by sexual contact, blood transfusions and vertically from mother to child during pregnancy. When symptomatic, clinical manifestations occur on average 3 to 7 days after mosquito virus inoculation and include fever, headache, arthralgia, myalgia, conjunctivitis, vomiting, fatigue, and maculopapular rash. The aim of the present study was evaluate the presence of Zika virus in whole blood samples or serum of patients with suspected clinical infection with this pathogen. A total of 353 serum or whole blood samples from various cities of the state of Rio Grande do Norte collected from 2014 to 2015 were analyzed. The samples were processed for total RNA extraction, cDNA synthesis and reverse transcription followed by real-time polymerase chain reaction (RT-qPCR) using primers required for a region of the viral genome. The overall prevalence rate of infection in the study period was 17.6%, 10.4% in 2014 and 21.0% in 2015. The distribution of confirmed cases of disease according to gender showed that rates prevalence were practically the same for men and women with values of 17.3% and 17.7%, respectively. Cases of Zika virus infection were diagnosed in all age groups, but most of the infected patients were aged up to 50 years with a reduction in the number of cases after 51 years of age. The results show a peak of incidence of virus infection in 2015, reaching similar men and women, especially in the 0-50 age group. |
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