Revisão: atividade antibacteriana de peptídeos nativos e análogos de escorpião
One of the world greatest problem in public health to be faced in the next years is the bacterial resistance question on health institutions. Many studies has been performed by a lot of research groups in order to reduce this problem through researches that seek for alternative molecules to rise up...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/41594 |
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| Resumo: | One of the world greatest problem in public health to be faced in the next years is the bacterial resistance question on health institutions. Many studies has been performed by a lot of research groups in order to reduce this problem through researches that seek for alternative molecules to rise up the therapeutic arsenal against the infectious diseases, mainly with regards to the bacterial infectious diseases. In this way, a group of molecules has gained notoriety like candidates to become a fine alternative in this biological war, the called antimicrobial peptides (AMPs). Such peptides can have natural origin, found in many sources, like plants, arthropods, another animals (amphibians, humans), prokaryotes; can be synthetic, such as the native peptides analogs; can be recombinant peptides, obtained by the recombinant DNA technology, through the coding antimicrobial peptide’s gene allocation on any life being or cells culture, giving to them the ability to produce such peptide (GANZ; LEHRER, 1999; LI et al., 2012).
In this way, the following review will approach specifically the antibacterial peptides isolated from scorpion venom, animals that, by the way, have been considered one of the greatest sources of natural antimicrobial biomolecules (PRIMON-BARROS; JOSE MACEDO, 2017). Among the antimicrobial peptides (AMP) with antibacterial activity isolated from the scorpion venom, we can cite molecules like Stigmurin, isolated from the Tytius stigmurus scorpion venom (DE MELO et al., 2015; DANIELE-SILVA et al., 2016); the hadrurins isolated from the Hadrurus aztecus scorpion venom (TORRES-LARIOS et al., 2000; SANCHEZ-VASQUEZ et al., 2013); the IsCT peptide, found in Opithancatus madagascariensis scorpion venom (DAI et al., 2002; DE LA SALUD BEA et al., 2017); the BmKn2 peptide isolated from the Buthus martensii scorpion venom (CAO et al., 2012). Besides, there are literature reports presenting alternative activities for these antimicrobial peptides isolated from scorpion venom, such as antifungal, antiparasitic, antiviral and, even, anticancer (WANG; WANG, 2016; PEDRON et al., 2018). In common, such peptides share the cationic character due to the presence of basic amino acids like lysine and arginine, presenting or not presenting disulfide bridges. AMPs without disulfide bridges isolated from scorpions, in general, can change their structural conformations depending on the media inserted, with such flexibility having to do with the disruptive mechanism of the bacterial membrane surface, and, consequently, having to do with the execution of their antibacterial effect. In general, the mainly reported mechanism of action to AMPs (including the AMPs isolated from scorpions) involves 3 models: the toroidal pore model, the carpet like model and the barrel stave model (HARRISON et al., 2014; FRATINI et al., 2017). In view of the above, the objective of this review is to present to the reader a research line that aims to contribute to new therapeutic possibilities in the face of the problem of gradual increase of bacterial resistance in clinical practice, specifically focusing on the antimicrobial peptides of antibacterial action isolated from scorpion’s venom and their analogues (new peptides with antibacterial action modified from the natives with the same property, aiming at improving the antibacterial activity or aiming to improve the therapeutic safety of the native peptides), molecules that are promising, in the most recent studies, regarding their in vitro antibacterial activity and in animal models, presenting as a possible alternative, to be used as a prototype to obtain new antibacterial agents. |
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