Resistência à insulina e perfil lipídico em adolescentes com sobrepeso e obesidade
Introduction: Insulin resistance (IR) is characterized by impaired insulin action in peripheral glucose uptake and associated with a higher risk of metabolic complications, especially in obese individuals. Objective: The study aimed to evaluate the frequency of IR and its association with lipid prof...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/40137 |
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| Resumo: | Introduction: Insulin resistance (IR) is characterized by impaired insulin action in peripheral glucose uptake and associated with a higher risk of metabolic complications, especially in obese individuals. Objective: The study aimed to evaluate the frequency of IR and its association with lipid profile in overweight adolescents. Methodology: Cross-sectional study, approved by the Research Ethics Committee, involving overweight or obese adolescents aged 10-19 years attending a pediatric endocrinology outpatient clinic. Anthropometric data (weight and height) were collected and analyzed to calculate Body Mass Index and Biochemicals (total cholesterol, LDL-c, HDL-c, triglycerides, insulin and fasting glucose). The HOMA-IR Index (Homeostatic Model Assessment) was calculated and the cutoff point ≥ 3.16 was adopted to diagnose insulin resistance. Data were evaluated by descriptive statistics and Chi-square test, Student T test and Pearson correlation were applied. For all tests a 95% confidence level was used and p-value <0.05 was considered statistically significant. Results: A total of 124 adolescents were evaluated, with a mean age of 11.4 (1.52) years, most of them male (52.4%). A frequency of 32.3% of adolescents with IR was identified, being more evident in females (p = 0.001). Overall BMI averages of 26.5 kg / m² (3.59), fasting blood glucose were found. 94.10 mg / dl (7.43) and fasting insulin of 12.76 (11.89). It was observed that adolescents with IR had higher mean fasting glucose (p = 0.001) and triglycerides (p = 0.001), and lower mean HDL-c (p = 0.005) when compared to those without IR. There was an association between IR and low HDL-c concentrations (PR 1.28, CI 1.02-1.61), high triglycerides (RP 1.39, CI 1.11-1.74) and blood glucose. high (RP 1.88, CI 1.14-3.07). There was a positive correlation between IR and triglyceride values (r = 0.185, p = 0.038) and fasting glucose (r = 0.328, p = 0.001) and a negative correlation with HDL-c values (r = - 0.287, p = 0.001). Conclusion: There was a high percentage of IR among overweight adolescents, more frequently in females. Adolescents with IR showed alterations in serum HDL-c, TG and fasting glucose levels. |
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