Produção de fitas de tricálcio fosfato e hidroxiapatita via tape casting
The search for new materials that improve bone regeneration has been growing more and more, which has enabled the development of devices with the same crystallinity pattern of bone, allowing the replacement, restoration and restructuring of lost tissue functions. Calcium phosphates due to the great...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/38742 |
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| Resumo: | The search for new materials that improve bone regeneration has been growing more and more, which has enabled the development of devices with the same crystallinity pattern of bone, allowing the replacement, restoration and restructuring of lost tissue functions. Calcium phosphates due to the great chemical and biological similarity with bone tissues have been extensively investigated to improve bone regeneration, as they have low mechanical resistance and excellent promoters of new bone formation. Some ions with a calcium-like charge can be incorporated into calcium phosphates to form associations with biological apatites. Studies point to the use of manganese as an enhancer of the biocompatibility of hydroxyapatites and tricalcium phosphates, in addition to activating magnetic properties, since the element is secreted in the form of magnetic nanodomains. The objective of this work was the development of hydroxyapatite and tricalcium phosphate ceramic membranes using the Tape Casting technique to be used as a bone dressing in bone tissue regeneration. For the development of these membranes, ceramic suspensions based on polymers were produced to optimize the mechanical properties. Among these polymers, poly (vinyl alcohol) - PVA was used, which is a synthetic material with good biocompatibility. Due to the rapid degradability presented by PVA, it was necessary to add a crosslinking agent to the ceramic suspension, since the negative interference in cell osteogenesis reduces the interaction time between the material and the bone. The suspensions obtained were characterized by physical-chemical tests, such as rheology analysis, and the tapes subjected to thermal analysis (ATG and ATD), X-ray diffraction (XRD), degree of swelling, morphological tests, such as electron microscopy of scanning (SEM), and in vitro assays, such as bioactivity and cytotoxicity. The potential of the tapes obtained as a bone dressing for tissue regeneration was evaluated. The results showed that the suspensions produced showed a pseudoplastic behavior, necessary for the technique via Tape Casting. The XRD analyzes allowed to observe the phases β-TCP and Hydroxyapatite. The degree of swelling and thermal analysis validated the presence of citric acid as a crosslinking agent, as they were resistant to water and to the increase in the temperature of the medium. Biocompatibility analyzes confirmed the low bioactivity of the membrane and are non-toxic, which is suitable for use in bone tissue. |
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