Extrato a base de taninos da casca da Azadirachta indica A Juss. e seu potencial antioxidante e antibacteriano

The search for alternative medicines of natural origin is growing, mainly due to the inefficiency of the drugs currently used for the treatment of diseases caused by super-bacteria and/or oxidative stresses. The barks of plants, on the other hand, present themselves as a source of bioactive capable...

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Autor principal: Maia, Dara Rodrigues
Outros Autores: Azevedo, Tatiane Kelly Barbosa de
Formato: bachelorThesis
Idioma:pt_BR
Publicado em: Universidade Federal do Rio Grande do Norte
Assuntos:
compostos bioativos
fitofármacos
polifenóis
bioactive compounds
phytopharmaceuticals
polyphenols
Endereço do item:https://repositorio.ufrn.br/handle/123456789/38286
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id ri-123456789-38286
record_format dspace
institution Repositório Institucional
collection RI - UFRN
language pt_BR
topic compostos bioativos
fitofármacos
polifenóis
bioactive compounds
phytopharmaceuticals
polyphenols
spellingShingle compostos bioativos
fitofármacos
polifenóis
bioactive compounds
phytopharmaceuticals
polyphenols
Maia, Dara Rodrigues
Extrato a base de taninos da casca da Azadirachta indica A Juss. e seu potencial antioxidante e antibacteriano
description The search for alternative medicines of natural origin is growing, mainly due to the inefficiency of the drugs currently used for the treatment of diseases caused by super-bacteria and/or oxidative stresses. The barks of plants, on the other hand, present themselves as a source of bioactive capable of treating different diseases. Among the chemical compounds of the barks with medicinal properties, tannins stand out. Thus, this work aimed to characterize and verify the antioxidant and antimicrobial potential of the tannin-based extract of the stem bark of Azadirachta indica A Juss. The bark was collected from five individuals located in the experimental plantation of the Federal University of Rio Grande do Norte, Macaíba Campus. They were dried and ground to reduce their granulometry. Then the phenolic compounds were extracted and the total solid content (TST), Stiasny index (I), condensed tannin content (CTT), non-tannin content (NTC), and tannins per ton of dry bark were determined. Antioxidant activity was determined by the DPPH method. For antimicrobial activity, the disk diffusion method was applied using gram-positive and negative bacteria. The mean value found for TST, I, TTC was 6.91, 67.4, and 6.88%, respectively. The antioxidant activity showed an IC50 value of 4.69 µg/mL-1. The most sensitive bacteria to the use of tannic extract was Staphylococcus aureus, with an average halo of inhibition of 12.4 mm. Therefore, the tannic extract of A. indica presents itself as a source of bioactive with therapeutic capacity and can serve as a basis for the development of different products in the pharmaceutical, cosmetic, and food industries.
author2 Azevedo, Tatiane Kelly Barbosa de
author_facet Azevedo, Tatiane Kelly Barbosa de
Maia, Dara Rodrigues
format bachelorThesis
author Maia, Dara Rodrigues
author_sort Maia, Dara Rodrigues
title Extrato a base de taninos da casca da Azadirachta indica A Juss. e seu potencial antioxidante e antibacteriano
title_short Extrato a base de taninos da casca da Azadirachta indica A Juss. e seu potencial antioxidante e antibacteriano
title_full Extrato a base de taninos da casca da Azadirachta indica A Juss. e seu potencial antioxidante e antibacteriano
title_fullStr Extrato a base de taninos da casca da Azadirachta indica A Juss. e seu potencial antioxidante e antibacteriano
title_full_unstemmed Extrato a base de taninos da casca da Azadirachta indica A Juss. e seu potencial antioxidante e antibacteriano
title_sort extrato a base de taninos da casca da azadirachta indica a juss. e seu potencial antioxidante e antibacteriano
publisher Universidade Federal do Rio Grande do Norte
publishDate 2021
url https://repositorio.ufrn.br/handle/123456789/38286
work_keys_str_mv AT maiadararodrigues extratoabasedetaninosdacascadaazadirachtaindicaajusseseupotencialantioxidanteeantibacteriano
AT maiadararodrigues tanninbasedextractfromthebarkofazadirachtaindicaajussanditsantioxidantandantibacterialpotential
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spelling ri-123456789-382862021-10-19T22:17:23Z Extrato a base de taninos da casca da Azadirachta indica A Juss. e seu potencial antioxidante e antibacteriano Tannin-based extract from the bark of Azadirachta indica A Juss. and it's antioxidant and antibacterial potential Maia, Dara Rodrigues Azevedo, Tatiane Kelly Barbosa de http://lattes.cnpq.br/1141765931117823 http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4167335A9 Ucella-Filho, João Gilberto Meza http://lattes.cnpq.br/8441792944532943 Azevedo, Tatiane Kelly Barbosa De http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4167335A9 Souza, Elias Costa de http://lattes.cnpq.br/2443233154986868 Marques Junior, Sergio http://lattes.cnpq.br/3095760811566254 compostos bioativos fitofármacos polifenóis bioactive compounds phytopharmaceuticals polyphenols The search for alternative medicines of natural origin is growing, mainly due to the inefficiency of the drugs currently used for the treatment of diseases caused by super-bacteria and/or oxidative stresses. The barks of plants, on the other hand, present themselves as a source of bioactive capable of treating different diseases. Among the chemical compounds of the barks with medicinal properties, tannins stand out. Thus, this work aimed to characterize and verify the antioxidant and antimicrobial potential of the tannin-based extract of the stem bark of Azadirachta indica A Juss. The bark was collected from five individuals located in the experimental plantation of the Federal University of Rio Grande do Norte, Macaíba Campus. They were dried and ground to reduce their granulometry. Then the phenolic compounds were extracted and the total solid content (TST), Stiasny index (I), condensed tannin content (CTT), non-tannin content (NTC), and tannins per ton of dry bark were determined. Antioxidant activity was determined by the DPPH method. For antimicrobial activity, the disk diffusion method was applied using gram-positive and negative bacteria. The mean value found for TST, I, TTC was 6.91, 67.4, and 6.88%, respectively. The antioxidant activity showed an IC50 value of 4.69 µg/mL-1. The most sensitive bacteria to the use of tannic extract was Staphylococcus aureus, with an average halo of inhibition of 12.4 mm. Therefore, the tannic extract of A. indica presents itself as a source of bioactive with therapeutic capacity and can serve as a basis for the development of different products in the pharmaceutical, cosmetic, and food industries. A busca por medicamentos alternativos de origem natural é crescente, em virtude, principalmente, da ineficiência dos fármacos utilizados atualmente para o tratamento de doenças causadas por superbactérias e/ou estresses oxidativos. As cascas das plantas, por sua vez, se apresentam como fonte de bioativos capazes de tratar diferentes enfermidades. Dentre os compostos químicos das cascas com propriedades medicinais se destacam os taninos. Desse modo, este trabalho teve por objetivo caracterizar e verificar o potencial antioxidante e antimicrobiano do extrato a base de taninos da casca do caule do Nim. As cascas foram coletadas de cinco indivíduos da espécie localizados em plantio experimental da Universidade Federal do Rio Grande do Norte, no Campus Macaíba. Estas foram secas e moídas para redução de sua granulometria. Em seguida foram realizadas a extração dos compostos fenólicos e determinados o teor de sólidos totais (TST), índice de Stiasny (I), teor de taninos condensados (TTC), teor de não taninos (TNT) e taninos por toneladas de casca seca (TTS). A atividade antioxidante foi determinada por varredura do radical 2,2-difenil-1-picril-hidrazila (DPPH). Para atividade antimicrobiana foi aplicado o método de difusão em disco utilizando bactérias gram-positivas e negativas. O valor médio encontrado para TST, I e TTC foram, respectivamente, 6,91, 67,4 e 6,88%. A atividade antioxidante apresentou valor de IC50 de 4,69 µg/mL-1. A bactéria mais sensível ao uso do extrato foi Staphylococcus aureus, com halo de inibição médio de 12,4 mm. Portanto, o extrato tânico da A. indica apresenta-se como fonte de bioativos com capacidade terapêutica, podendo servir de base para desenvolvimento de diferentes produtos nas industriais farmacêuticas, cosméticos e alimentícias. 2021-09-27T11:44:07Z 2021-09-27T11:44:07Z 2021-09-10 bachelorThesis MAIA, Dara Rodrigues. Extrato a base de taninos da casca da Azadirachta indica A Juss. e seu potencial antioxidante e antibacteriano. 2021. 43f. Trabalho de Conclusão de Curso (Graduação em Engenharia Florestal), Unidade Acadêmica Especializada em Ciências Agrárias, Universidade Federal do Rio Grande do Norte, Macaíba, 2021. https://repositorio.ufrn.br/handle/123456789/38286 pt_BR Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Universidade Federal do Rio Grande do Norte Brasil UFRN Engenharia Florestal Unidade Acadêmica Especializada em Ciências Agrárias

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