Obtenção e caracterização de membranas de quitosana reticuladas com potencial para adsorção de tetraciclina
Chitosan (CS), a chitin-derived biopolymer that is a widely distributed polymer in nature present in the crustacean exoskeleton, has been evaluated through the production of crosslinked and non-crosslinked membranes. Investigation of the adsorption capacity of sulfuric acid cross-linked and non-c...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/38209 |
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| Resumo: | Chitosan (CS), a chitin-derived biopolymer that is a widely distributed polymer
in nature present in the crustacean exoskeleton, has been evaluated through the
production of crosslinked and non-crosslinked membranes. Investigation of the
adsorption capacity of sulfuric acid cross-linked and non-crosslinked chitosan
membranes was investigated using the drug tetracycline. Adsorption studies were
conducted at temperature of the 37 ° C and pH of the 6.8. For the preparation of
chitosan membranes an experimental methodology was developed to improve the
yield a is obtaining of crosslinked and non-crosslinked chitosan membranes. The drug
tetracycline was used as a model in the adsorption study which was followed by
reading on the UV-Vis spectrophotometer in 358 nm. The crosslinked and noncrosslinked membranes were characterized by infrared, X-ray diffraction and thermal
analysis (DSC). Swelling index and crystallinity percentage measurements of CS
membranes were also performed to evaluate the influence of sulfuric acid addition.
DSC and XRD analysis showed that tetracycline was partially adsorbed to the
membrane after 74 hours, reducing its concentration in the solution by up to 5 times
the initial concentration in the pure CS membrane. Water sorption, evaluated by
swelling index at pH 6.8, showed that sulfuric acid crosslinked membranes did not
interfere with water sorption capacity when compared to pure CS membrane. The
adsorption studies concluded that the pure CS membrane presented a higher capacity
to adsorb tetracycline. Through comparative analysis between infrared spectra it was
possible to confirm the incorporation of tetracycline, besides evaluating the influence
of the crosslinking process. |
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