Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®

Ferulic acid (FA) is a substance with promising activities, however, its limited aqueous solubility impairs the obtaining of new formulations. Several technological strategies have been developed to increase the solubility of drugs, among which there are amorphous solid dispersions (ASD). Thus, the...

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Autor principal: Albuquerque, Ingrid da Silva
Outros Autores: de Lima, Ádley
Formato: bachelorThesis
Idioma:English
Publicado em: Universidade Federal do Rio Grande do Norte
Assuntos:
Ferulic Acid
Amorphous Solid Dispersions
Soluplus®
Endereço do item:https://repositorio.ufrn.br/handle/123456789/35821
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spelling ri-123456789-358212021-09-20T17:52:28Z Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus® Albuquerque, Ingrid da Silva de Lima, Ádley Fernanda Ílary Costa Duarte Oliveira , Verônica Gomes, Ana Paula Ferulic Acid Amorphous Solid Dispersions Soluplus® Ferulic acid (FA) is a substance with promising activities, however, its limited aqueous solubility impairs the obtaining of new formulations. Several technological strategies have been developed to increase the solubility of drugs, among which there are amorphous solid dispersions (ASD). Thus, the aim of the present study was to develop an ASD containing FA using different obtaining methods. Soluplus® was selected by solubility study with FA, from this were obtained ASD with ferulic acid by physical mixture (PM), kneading (KND) and evaporation rotary (ER). The solid dispersions were quantified by UV/Vis spectrophotometry and characterized physical-chemically by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and differential exploratory calorimetry (DSC). The results demonstrated the formation of amorphous solid dispersion through the techniques used, and KND and ER showed better results with significant reductions in the intensities of crystalline reflections by the XRD, as well as in the intensity of the bands in the FTIR and the absence of the characteristic fusion peak of AF in the DSC of the samples. Thus, it can be concluded that solid dispersions with ferulic acid were obtained, which will be investigated later for dissolution and antioxidant activity in vitro. 2020-07-09T14:17:25Z 2021-09-20T17:52:28Z 2020-07-09T14:17:25Z 2021-09-20T17:52:28Z 2020-06-18 bachelorThesis 2016082163 ALBUQUERQUE, Ingrid da Silva. Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and Soluplus®. 2020. 39f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2020. https://repositorio.ufrn.br/handle/123456789/35821 en application/octet-stream Universidade Federal do Rio Grande do Norte Brasil UFRN Farmácia
institution Repositório Institucional
collection RI - UFRN
language English
topic Ferulic Acid
Amorphous Solid Dispersions
Soluplus®
spellingShingle Ferulic Acid
Amorphous Solid Dispersions
Soluplus®
Albuquerque, Ingrid da Silva
Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®
description Ferulic acid (FA) is a substance with promising activities, however, its limited aqueous solubility impairs the obtaining of new formulations. Several technological strategies have been developed to increase the solubility of drugs, among which there are amorphous solid dispersions (ASD). Thus, the aim of the present study was to develop an ASD containing FA using different obtaining methods. Soluplus® was selected by solubility study with FA, from this were obtained ASD with ferulic acid by physical mixture (PM), kneading (KND) and evaporation rotary (ER). The solid dispersions were quantified by UV/Vis spectrophotometry and characterized physical-chemically by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and differential exploratory calorimetry (DSC). The results demonstrated the formation of amorphous solid dispersion through the techniques used, and KND and ER showed better results with significant reductions in the intensities of crystalline reflections by the XRD, as well as in the intensity of the bands in the FTIR and the absence of the characteristic fusion peak of AF in the DSC of the samples. Thus, it can be concluded that solid dispersions with ferulic acid were obtained, which will be investigated later for dissolution and antioxidant activity in vitro.
author2 de Lima, Ádley
author_facet de Lima, Ádley
Albuquerque, Ingrid da Silva
format bachelorThesis
author Albuquerque, Ingrid da Silva
author_sort Albuquerque, Ingrid da Silva
title Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®
title_short Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®
title_full Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®
title_fullStr Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®
title_full_unstemmed Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®
title_sort selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®
publisher Universidade Federal do Rio Grande do Norte
publishDate 2020
url https://repositorio.ufrn.br/handle/123456789/35821
work_keys_str_mv AT albuquerqueingriddasilva selectionofsuitablepolymerandobtainingnewamorphoussoliddispersionswithferulicacidandsoluplus
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