Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use

Ibuprofen (IBF) is a non-steroidal anti-inflammatory drug (NSAID) that has analgesic, antipyretic and anti-inflammatory action, but is a poorly soluble drug. Aiming at improving the bioavailability of this drug, this study aimed to develop ibuprofen-containing nanoemulsions (NE) and gelatinized nano...

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Autor principal: Santos, Milena Lima Valério dos
Outros Autores: Silva Júnior, Arnóbio Antônio da
Formato: bachelorThesis
Idioma:English
Publicado em: Universidade Federal do Rio Grande do Norte
Assuntos:
Nanoemulsion
Nanogel
Ibuprofen
Poloxamer 407
Endereço do item:https://repositorio.ufrn.br/handle/123456789/35774
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spelling ri-123456789-357742024-03-19T04:01:15Z Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use Santos, Milena Lima Valério dos Silva Júnior, Arnóbio Antônio da Lucas Azevedo do Nascimento Medeiros, Arthur Sérgio Avelino de Silva, Edilamar Pereira da Nanoemulsion Nanogel Ibuprofen Poloxamer 407 Ibuprofen (IBF) is a non-steroidal anti-inflammatory drug (NSAID) that has analgesic, antipyretic and anti-inflammatory action, but is a poorly soluble drug. Aiming at improving the bioavailability of this drug, this study aimed to develop ibuprofen-containing nanoemulsions (NE) and gelatinized nanoemulsions (NEG) for possible topical use. Nanoemulsions were prepared using low energy technique at different surfactant concentrations. For the gelation of nanoemulsions a copolymer with thermoreversible properties was used in different proportions, being Poloxamer 407 (Pluronic F127®). The characteristics of both systems were evaluated with respect to average droplet size, polydispersion index and zeta potential. All samples presented nanometer droplet size and negative zeta potential; The polydispersion index values were variable. The selected nanoemulsion was translucent and had stable droplet size and polydispersion index over a period of 60 days. This system then received ibuprofen and the same characteristics were evaluated and the formulation was stable for 15 days. Afterwards, the empty and drug nanoemulsions were gelled with Pluronic F127® (F127) and maintained their stability for more than 40 days, maintaining their nanometric characteristics during the study. In addition, the in vitro release study showed that within 6 hours, it is possible that about 50% of the drug will be released, and after that release will remain constant. Thus, we can see that the development of NE can improve the bioavailability of IBF and that nanogels are a vehicle option for improving topical administration of this drug. 2022-01-01 2019-11-22T19:46:11Z 2021-09-20T17:51:12Z 2019-11-22T19:46:11Z 2019-11-06 bachelorThesis 20150118353 SANTOS, Milena Lima Valério dos. Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use. 2019. 26f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019. https://repositorio.ufrn.br/handle/123456789/35774 en Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Universidade Federal do Rio Grande do Norte Brasil UFRN Farmácia
institution Repositório Institucional
collection RI - UFRN
language English
topic Nanoemulsion
Nanogel
Ibuprofen
Poloxamer 407
spellingShingle Nanoemulsion
Nanogel
Ibuprofen
Poloxamer 407
Santos, Milena Lima Valério dos
Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
description Ibuprofen (IBF) is a non-steroidal anti-inflammatory drug (NSAID) that has analgesic, antipyretic and anti-inflammatory action, but is a poorly soluble drug. Aiming at improving the bioavailability of this drug, this study aimed to develop ibuprofen-containing nanoemulsions (NE) and gelatinized nanoemulsions (NEG) for possible topical use. Nanoemulsions were prepared using low energy technique at different surfactant concentrations. For the gelation of nanoemulsions a copolymer with thermoreversible properties was used in different proportions, being Poloxamer 407 (Pluronic F127®). The characteristics of both systems were evaluated with respect to average droplet size, polydispersion index and zeta potential. All samples presented nanometer droplet size and negative zeta potential; The polydispersion index values were variable. The selected nanoemulsion was translucent and had stable droplet size and polydispersion index over a period of 60 days. This system then received ibuprofen and the same characteristics were evaluated and the formulation was stable for 15 days. Afterwards, the empty and drug nanoemulsions were gelled with Pluronic F127® (F127) and maintained their stability for more than 40 days, maintaining their nanometric characteristics during the study. In addition, the in vitro release study showed that within 6 hours, it is possible that about 50% of the drug will be released, and after that release will remain constant. Thus, we can see that the development of NE can improve the bioavailability of IBF and that nanogels are a vehicle option for improving topical administration of this drug.
author2 Silva Júnior, Arnóbio Antônio da
author_facet Silva Júnior, Arnóbio Antônio da
Santos, Milena Lima Valério dos
format bachelorThesis
author Santos, Milena Lima Valério dos
author_sort Santos, Milena Lima Valério dos
title Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
title_short Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
title_full Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
title_fullStr Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
title_full_unstemmed Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
title_sort development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
publisher Universidade Federal do Rio Grande do Norte
publishDate 2019
url https://repositorio.ufrn.br/handle/123456789/35774
work_keys_str_mv AT santosmilenalimavaleriodos developmentofthermoresponsiveibuprofennanoemulsionbasedgelforpotentialtopicaluse
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