Isolamento e purificação de droga psicotrópica

Increased ecstasy use and drug trafficking, in addition to the use of different substances to adulterate and mask the identification tests used by the police, demands the development of new isolation and purification methodologies that may assist in the characterization and elucidation of samples in...

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Autor principal: Miranda, Matheus Leopoldo de Oliveira
Outros Autores: Ferreira, Leandro de Santis
Formato: bachelorThesis
Idioma:English
Publicado em: Universidade Federal do Rio Grande do Norte
Assuntos:
Ecstasy
MDMA
Isolation
Purification
Sephadex™ LH-20
Sílica Gel 60
Endereço do item:https://repositorio.ufrn.br/handle/123456789/35769
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spelling ri-123456789-357692021-09-20T17:51:03Z Isolamento e purificação de droga psicotrópica Psicotropic drug isolation and purifying Miranda, Matheus Leopoldo de Oliveira Ferreira, Leandro de Santis Ferreira, Leandro De Santis Gomes, Ana Paula Barreto Gomes, Cezar Silvino Ecstasy MDMA Isolation Purification Sephadex™ LH-20 Sílica Gel 60 Increased ecstasy use and drug trafficking, in addition to the use of different substances to adulterate and mask the identification tests used by the police, demands the development of new isolation and purification methodologies that may assist in the characterization and elucidation of samples in future seizures. This study, through a partnership between UFRN and the Federal Police, proposed the isolation and characterization of 3,4-methylenedioxymethamphetamine (MDMA) from a sample seized in the state of Rio Grande do Norte, in order to contribute to the obtaining of a substance. that can be used to identify seized material, besides allowing the development and validation of analytical methodology to quantify these compounds. The work presents the comparison between classical column isolation methodologies and the development of a selective analytical method for the determination of MDMA, using gas chromatography coupled to the mass spectrometer (GC-MS). Isolation was compared using classic column chromatography containing Sephadex™ LH-20 (exclusion) and column with Silica Gel 60 (0.063-0.200 mm) (adsorption). The two isolation methodologies used demonstrated efficiency in the seized MDMA purification process. Exclusion chromatography yielded about 5% yield and 100% purity, while adsorption chromatography was shown to produce 10% yield and 100% purity. Identification was performed by comparison with library mass spectra and by retention time. Thus, this study allows the use of MDMA as an analytical standard in PF-RN quantification and identification methodology as also the development of new studies such as process scheduling or increasing yield. 2019-11-22T16:53:02Z 2021-09-20T17:51:03Z 2019-11-22T16:53:02Z 2021-09-20T17:51:03Z 2019-11-06 bachelorThesis 2014094746 MIRANDA, Matheus Leopoldo de Oliveira. Isolamento e purificação de droga psicotrópica. 2019. 19f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019. https://repositorio.ufrn.br/handle/123456789/35769 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Universidade Federal do Rio Grande do Norte Brasil UFRN Farmácia
institution Repositório Institucional
collection RI - UFRN
language English
topic Ecstasy
MDMA
Isolation
Purification
Sephadex™ LH-20
Sílica Gel 60
spellingShingle Ecstasy
MDMA
Isolation
Purification
Sephadex™ LH-20
Sílica Gel 60
Miranda, Matheus Leopoldo de Oliveira
Isolamento e purificação de droga psicotrópica
description Increased ecstasy use and drug trafficking, in addition to the use of different substances to adulterate and mask the identification tests used by the police, demands the development of new isolation and purification methodologies that may assist in the characterization and elucidation of samples in future seizures. This study, through a partnership between UFRN and the Federal Police, proposed the isolation and characterization of 3,4-methylenedioxymethamphetamine (MDMA) from a sample seized in the state of Rio Grande do Norte, in order to contribute to the obtaining of a substance. that can be used to identify seized material, besides allowing the development and validation of analytical methodology to quantify these compounds. The work presents the comparison between classical column isolation methodologies and the development of a selective analytical method for the determination of MDMA, using gas chromatography coupled to the mass spectrometer (GC-MS). Isolation was compared using classic column chromatography containing Sephadex™ LH-20 (exclusion) and column with Silica Gel 60 (0.063-0.200 mm) (adsorption). The two isolation methodologies used demonstrated efficiency in the seized MDMA purification process. Exclusion chromatography yielded about 5% yield and 100% purity, while adsorption chromatography was shown to produce 10% yield and 100% purity. Identification was performed by comparison with library mass spectra and by retention time. Thus, this study allows the use of MDMA as an analytical standard in PF-RN quantification and identification methodology as also the development of new studies such as process scheduling or increasing yield.
author2 Ferreira, Leandro de Santis
author_facet Ferreira, Leandro de Santis
Miranda, Matheus Leopoldo de Oliveira
format bachelorThesis
author Miranda, Matheus Leopoldo de Oliveira
author_sort Miranda, Matheus Leopoldo de Oliveira
title Isolamento e purificação de droga psicotrópica
title_short Isolamento e purificação de droga psicotrópica
title_full Isolamento e purificação de droga psicotrópica
title_fullStr Isolamento e purificação de droga psicotrópica
title_full_unstemmed Isolamento e purificação de droga psicotrópica
title_sort isolamento e purificação de droga psicotrópica
publisher Universidade Federal do Rio Grande do Norte
publishDate 2019
url https://repositorio.ufrn.br/handle/123456789/35769
work_keys_str_mv AT mirandamatheusleopoldodeoliveira isolamentoepurificacaodedrogapsicotropica
AT mirandamatheusleopoldodeoliveira psicotropicdrugisolationandpurifying
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