Tuberculose multirresistente no Brasil

Tuberculosis (TB) is a chronic infectious disease, mainly caused by Mycobacterium tuberculosis, also known as Koch's bacillus (BK). Although TB is a curable disease, it remains one of the top ten causes of death in the world. One of the main obstacles to the control of the disease is the lack o...

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Autor principal: Almeida, Arthur Neri Marques Reis de
Outros Autores: Abrantes, Maiza Rocha de
Formato: bachelorThesis
Idioma:pt_BR
Publicado em: Universidade Federal do Rio Grande do Norte
Assuntos:
Tuberculose
Mycobacterium tuberculosis
Tuberculose Multidroga Resistente
Endereço do item:https://repositorio.ufrn.br/handle/123456789/35761
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spelling ri-123456789-357612021-09-28T16:49:35Z Tuberculose multirresistente no Brasil Almeida, Arthur Neri Marques Reis de Abrantes, Maiza Rocha de Francisco de Assis Bezerra Neto Silveira , Ivanaldo Amâncio da Souza , Luanda Bárbara Ferreira Canário de Tuberculose Mycobacterium tuberculosis Tuberculose Multidroga Resistente Tuberculosis (TB) is a chronic infectious disease, mainly caused by Mycobacterium tuberculosis, also known as Koch's bacillus (BK). Although TB is a curable disease, it remains one of the top ten causes of death in the world. One of the main obstacles to the control of the disease is the lack of adherence to treatment, the inadequate and irregular use of medicines for an insufficient time, this makes BK resistant to antiTB. Resistance to these drugs has become a reality on the world stage, specifically when related to rifampicin and isoniazid, characterizing resistant multidrug TB (MDR-TB). As an objective, the work aims to carry out a literature review about tuberculosis and the implications of its state of multidrug resistance in brazil. The methodology it consisted of a reviewing the literature of articles, data from the Brazilian government, scientific journals, dissertations and academic theses using SciELO, Google Scholar, PubMed and MEDLINE in the period from 2013 to 2020. Twenty-seven documents were analyzed and, according to them, it was possible to determine which strategies such as knowledge of the biology of the etiologic agent, early diagnosis, knowledge of bacillus resistance mechanisms, drug sensitivity tests, appropriate treatment of the disease and epidemiological record of TB. All of these mechanisms are major determinants for the cure and reduction of mortality caused by the disease to be achieved more quickly, as well as the reduction of cases of MDR-TB. A Tuberculose (TB) é uma doença infectocontagiosa de natureza crônica, causada mais prevalentemente pelo Mycobacterium tuberculosis, também conhecido como bacilo de Koch (BK). Apesar da TB ser uma doença curável, continua sendo uma das dez maiores causas de morte no mundo. Um dos principais obstáculos para o controle da doença é a falta de adesão ao tratamento, o uso de forma inadequada e irregular dos medicamentos por tempo insuficiente, isso faz com que o BK se torne resistente aos antiTB. A resistência a esses fármacos vem se tornando uma realidade no cenário mundial, e também no brasil, quando relacionado à rifampicina e a isoniazida, caracterizando a TB multidroga resistente (MDR-TB). Como objetivo, o trabalho visa a realização de uma revisão de literatura a respeito da tuberculose e as implicações do seu estado de multirresistência a medicamentos no Brasil. A metodologia desse estudo consistiu na revisão de literatura de artigos, dados do governo brasileiro, periódicos científicos, dissertações e teses acadêmicas utilizando o SciELO, Google Acadêmico, PubMed e MEDLINE no período de 2013 a 2020. Foram analisados vinte e sete documentos e de acordo com eles foi possível determinar que estratégias como conhecimento da biologia do agente etiológico, diagnóstico precoce, conhecimento dos mecanismos de resistência do bacilo, testes de sensibilidade de fármacos, tratamento adequado da doença e registro epidemiológico da TB. Todos esses mecanismos são grandes determinantes para que seja alcançada de forma mais rápida a cura e a diminuição da mortalidade causada pela doença, assim como a redução de casos de MDR-TB. 2021-04-20T15:13:57Z 2021-09-20T17:50:48Z 2021-04-20T15:13:57Z 2021-09-20T17:50:48Z 2021-04-09 bachelorThesis 20150119575 Almeida, Arthur Neri Marques Reis de. Tuberculose multirresistente no Brasil. 2021. 52 f.Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Natal, 2021. https://repositorio.ufrn.br/handle/123456789/35761 pt_BR Attribution-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nd/3.0/br/ application/octet-stream Universidade Federal do Rio Grande do Norte Brasil UFRN Farmácia
institution Repositório Institucional
collection RI - UFRN
language pt_BR
topic Tuberculose
Mycobacterium tuberculosis
Tuberculose Multidroga Resistente
spellingShingle Tuberculose
Mycobacterium tuberculosis
Tuberculose Multidroga Resistente
Almeida, Arthur Neri Marques Reis de
Tuberculose multirresistente no Brasil
description Tuberculosis (TB) is a chronic infectious disease, mainly caused by Mycobacterium tuberculosis, also known as Koch's bacillus (BK). Although TB is a curable disease, it remains one of the top ten causes of death in the world. One of the main obstacles to the control of the disease is the lack of adherence to treatment, the inadequate and irregular use of medicines for an insufficient time, this makes BK resistant to antiTB. Resistance to these drugs has become a reality on the world stage, specifically when related to rifampicin and isoniazid, characterizing resistant multidrug TB (MDR-TB). As an objective, the work aims to carry out a literature review about tuberculosis and the implications of its state of multidrug resistance in brazil. The methodology it consisted of a reviewing the literature of articles, data from the Brazilian government, scientific journals, dissertations and academic theses using SciELO, Google Scholar, PubMed and MEDLINE in the period from 2013 to 2020. Twenty-seven documents were analyzed and, according to them, it was possible to determine which strategies such as knowledge of the biology of the etiologic agent, early diagnosis, knowledge of bacillus resistance mechanisms, drug sensitivity tests, appropriate treatment of the disease and epidemiological record of TB. All of these mechanisms are major determinants for the cure and reduction of mortality caused by the disease to be achieved more quickly, as well as the reduction of cases of MDR-TB.
author2 Abrantes, Maiza Rocha de
author_facet Abrantes, Maiza Rocha de
Almeida, Arthur Neri Marques Reis de
format bachelorThesis
author Almeida, Arthur Neri Marques Reis de
author_sort Almeida, Arthur Neri Marques Reis de
title Tuberculose multirresistente no Brasil
title_short Tuberculose multirresistente no Brasil
title_full Tuberculose multirresistente no Brasil
title_fullStr Tuberculose multirresistente no Brasil
title_full_unstemmed Tuberculose multirresistente no Brasil
title_sort tuberculose multirresistente no brasil
publisher Universidade Federal do Rio Grande do Norte
publishDate 2021
url https://repositorio.ufrn.br/handle/123456789/35761
work_keys_str_mv AT almeidaarthurnerimarquesreisde tuberculosemultirresistentenobrasil
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