Resistência bacteriana: uma investigação genômica baseada em mecanismos de resistência contra a azitromicina (2019-2021)
Azithromycin, an antibiotic of the macrolide class, has been widely used due to its activity against several infectious processes involving atypical and intracellular pathogens. The indiscriminate use of this drug also contributes to the emergence of bacterial resistance. According to the World H...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/33943 |
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| Resumo: | Azithromycin, an antibiotic of the macrolide class, has been widely used due to its activity
against several infectious processes involving atypical and intracellular pathogens. The
indiscriminate use of this drug also contributes to the emergence of bacterial resistance.
According to the World Health Organization, there is an estimate that bacterial resistance
will cause around 10 million deaths annually worldwide by the year 2050. Therefore, the
aim of this study was to carry out a systematic review of the literature, seeking genomic
information related to updates on bacterial resistance against azithromycin, through a
search in the Pubmed and Scopus databases, which resulted in the selection of 24 articles
from 2019 to 2021. In the proposed review, genomic information related to resistance
was obtained bacterial against azithromycin, including important data on some
microorganisms, such as: Neisseria gonorrhoeae, Salmonella Typhi, Streptococcus
pneumoniae, Mycoplasma genitalium, which demonstrate great versatility in the
development of resistance mechanisms against the aforementioned antimicrobial, through
mutation and expression of genes. Several in vitro studies are underway with the
participation of efflux pump inhibitors aimed at reducing resistance, with expressive
results in combating this phenomenon, but which require clinical investigation to
corroborate their application. |
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