Pathophysiology of major depression by clinical stages
The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms an...
Na minha lista:
| Principais autores: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Idioma: | English |
| Publicado em: |
Frontiers Media SA
|
| Assuntos: | |
| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/33046 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
| id |
ri-123456789-33046 |
|---|---|
| record_format |
dspace |
| spelling |
ri-123456789-330462021-08-09T11:47:59Z Pathophysiology of major depression by clinical stages Galvão, Ana Cecília de Menezes Almeida, Raíssa Nobrega Sousa Júnior, Geovan Menezes de Miguel, Mario André Leocadio Fontes, Fernanda Palhano Xavier de Araujo, Draulio Barros de Soares, Bruno Lobão Oliveira, João Paulo Maia de Nunes, Emerson Arcoverde Hallak, Jaime Eduardo Cecilio Schuch, Felipe Barreto Sarris, Jerome Galvão-Coelho, Nicole Leite Cortisol C-reactive protein Brain-derived neurotrophic factor Sleep quality Precision psychiatry The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms and sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including the levels of plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with MDD (n = 58) and a control group of healthy volunteers (n = 62). Patients with the first episode of MDD (n = 30) had significantly higher levels of CAR and SC than controls (n = 32) and similar levels of mBDNF of controls. Patients with treatment-resistant depression (TRD, n = 28) presented significantly lower levels of SC and CAR, and higher levels of mBDNF and CRP than controls (n = 30). An increased severity of depressive symptoms and worse sleep quality were correlated with levels low of SC and CAR, and with high levels of mBDNF. These results point out a strong relationship between the stages clinical of MDD and changes in a range of relevant biological markers. This can assist in the development of precision psychiatry and future research on the biological tests for depression 2021-08-09T11:47:59Z 2021-08-09T11:47:59Z 2021-08-05 article GALVÃO, Ana Cecília de Menezes; ALMEIDA, Raíssa Nobrega; SOUSA, Geovan Menezes de; LEOCADIO-MIGUEL, Mario André; PALHANO-FONTES, Fernanda; ARAUJO, Dráulio Barros de; LOBÃO-SOARES, Bruno; MAIA-DE-OLIVEIRA, João Paulo; NUNES, Emerson Arcoverde; HALLAK, Jaime Eduardo Cecilio. Pathophysiology of Major Depression by Clinical Stages. Frontiers In Psychology, [S.l.], v. 12, p. 641779, ago. 2021. Doi: http://dx.doi.org/10.3389/fpsyg.2021.641779. Disponível em: https://www.frontiersin.org/articles/10.3389/fpsyg.2021.641779/full. Acesso em: 5 ago. 2021. https://repositorio.ufrn.br/handle/123456789/33046 10.3389/fpsyg.2021.641779 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Frontiers Media SA |
| institution |
Repositório Institucional |
| collection |
RI - UFRN |
| language |
English |
| topic |
Cortisol C-reactive protein Brain-derived neurotrophic factor Sleep quality Precision psychiatry |
| spellingShingle |
Cortisol C-reactive protein Brain-derived neurotrophic factor Sleep quality Precision psychiatry Galvão, Ana Cecília de Menezes Almeida, Raíssa Nobrega Sousa Júnior, Geovan Menezes de Miguel, Mario André Leocadio Fontes, Fernanda Palhano Xavier de Araujo, Draulio Barros de Soares, Bruno Lobão Oliveira, João Paulo Maia de Nunes, Emerson Arcoverde Hallak, Jaime Eduardo Cecilio Schuch, Felipe Barreto Sarris, Jerome Galvão-Coelho, Nicole Leite Pathophysiology of major depression by clinical stages |
| description |
The comprehension of the pathophysiology of the major depressive disorder (MDD)
is essential to the strengthening of precision psychiatry. In order to determine the
relationship between the pathophysiology of the MDD and its clinical progression,
analyzed by severity of the depressive symptoms and sleep quality, we conducted a
study assessing different peripheral molecular biomarkers, including the levels of plasma
C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF),
serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with
MDD (n = 58) and a control group of healthy volunteers (n = 62). Patients with the first
episode of MDD (n = 30) had significantly higher levels of CAR and SC than controls
(n = 32) and similar levels of mBDNF of controls. Patients with treatment-resistant
depression (TRD, n = 28) presented significantly lower levels of SC and CAR, and higher
levels of mBDNF and CRP than controls (n = 30). An increased severity of depressive
symptoms and worse sleep quality were correlated with levels low of SC and CAR, and
with high levels of mBDNF. These results point out a strong relationship between the
stages clinical of MDD and changes in a range of relevant biological markers. This can
assist in the development of precision psychiatry and future research on the biological
tests for depression |
| format |
article |
| author |
Galvão, Ana Cecília de Menezes Almeida, Raíssa Nobrega Sousa Júnior, Geovan Menezes de Miguel, Mario André Leocadio Fontes, Fernanda Palhano Xavier de Araujo, Draulio Barros de Soares, Bruno Lobão Oliveira, João Paulo Maia de Nunes, Emerson Arcoverde Hallak, Jaime Eduardo Cecilio Schuch, Felipe Barreto Sarris, Jerome Galvão-Coelho, Nicole Leite |
| author_facet |
Galvão, Ana Cecília de Menezes Almeida, Raíssa Nobrega Sousa Júnior, Geovan Menezes de Miguel, Mario André Leocadio Fontes, Fernanda Palhano Xavier de Araujo, Draulio Barros de Soares, Bruno Lobão Oliveira, João Paulo Maia de Nunes, Emerson Arcoverde Hallak, Jaime Eduardo Cecilio Schuch, Felipe Barreto Sarris, Jerome Galvão-Coelho, Nicole Leite |
| author_sort |
Galvão, Ana Cecília de Menezes |
| title |
Pathophysiology of major depression by clinical stages |
| title_short |
Pathophysiology of major depression by clinical stages |
| title_full |
Pathophysiology of major depression by clinical stages |
| title_fullStr |
Pathophysiology of major depression by clinical stages |
| title_full_unstemmed |
Pathophysiology of major depression by clinical stages |
| title_sort |
pathophysiology of major depression by clinical stages |
| publisher |
Frontiers Media SA |
| publishDate |
2021 |
| url |
https://repositorio.ufrn.br/handle/123456789/33046 |
| work_keys_str_mv |
AT galvaoanaceciliademenezes pathophysiologyofmajordepressionbyclinicalstages AT almeidaraissanobrega pathophysiologyofmajordepressionbyclinicalstages AT sousajuniorgeovanmenezesde pathophysiologyofmajordepressionbyclinicalstages AT miguelmarioandreleocadio pathophysiologyofmajordepressionbyclinicalstages AT fontesfernandapalhanoxavierde pathophysiologyofmajordepressionbyclinicalstages AT araujodrauliobarrosde pathophysiologyofmajordepressionbyclinicalstages AT soaresbrunolobao pathophysiologyofmajordepressionbyclinicalstages AT oliveirajoaopaulomaiade pathophysiologyofmajordepressionbyclinicalstages AT nunesemersonarcoverde pathophysiologyofmajordepressionbyclinicalstages AT hallakjaimeeduardocecilio pathophysiologyofmajordepressionbyclinicalstages AT schuchfelipebarreto pathophysiologyofmajordepressionbyclinicalstages AT sarrisjerome pathophysiologyofmajordepressionbyclinicalstages AT galvaocoelhonicoleleite pathophysiologyofmajordepressionbyclinicalstages |
| _version_ |
1773962495001624576 |