Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches

The low-density lipoprotein receptor (LDLR) is key to cellular cholesterol uptake and is also the main receptor for the vesicular stomatitis virus glycoprotein (VSV G). Here we show that in songbirds LDLR is highly divergent and lacks domains critical for ligand binding and cellular trafficking, inc...

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Principais autores: Velho, Tarciso André Ferreira, Lovell, Peter V, Friedrich, Samantha R, Olson, Christopher R, Miles, Joshua, Mueller, Paul A, Tavori, Hagai, Fazio, Sergio, Lois, Carlos, Mello, Claudio V
Formato: article
Idioma:English
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Assuntos:
Cholesterol
LDLR
VSG G
Lentivirus
Viral transduction
Endereço do item:https://repositorio.ufrn.br/handle/123456789/32808
https://doi.org/10.1073/pnas.2025167118
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spelling ri-123456789-328082021-07-05T14:38:17Z Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches Velho, Tarciso André Ferreira Lovell, Peter V Friedrich, Samantha R Olson, Christopher R Miles, Joshua Mueller, Paul A Tavori, Hagai Fazio, Sergio Lois, Carlos Mello, Claudio V Cholesterol LDLR VSG G Lentivirus Viral transduction The low-density lipoprotein receptor (LDLR) is key to cellular cholesterol uptake and is also the main receptor for the vesicular stomatitis virus glycoprotein (VSV G). Here we show that in songbirds LDLR is highly divergent and lacks domains critical for ligand binding and cellular trafficking, inconsistent with universal structure conservation and function across vertebrates. Linked to the LDLR functional domain loss, zebra finches show inefficient infectivity by lentiviruses (LVs) pseudotyped with VSV G, which can be rescued by the expression of human LDLR. Finches also show an atypical plasma lipid distribution that relies largely on high-density lipoprotein (HDL). These findings provide insights into the genetics and evolution of viral infectivity and cholesterol transport mechanisms in vertebrates 2021-07-05T14:38:16Z 2021-07-05T14:38:16Z 2021-04-26 article VELHO, Tarciso A. F.; LOVELL, Peter V.; FRIEDRICH, Samantha R.; OLSON, Christopher R.; MILES, Joshua; MUELLER, Paul A.; TAVORI, Hagai; FAZIO, Sergio; LOIS, Carlos; MELLO, Claudio V.. Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches. Proceedings Of The National Academy Of Sciences, [S.L.], v. 118, n. 18, p. 2025167118, 26 abr. 2021. http://dx.doi.org/10.1073/pnas.2025167118. Disponível em: https://www.pnas.org/content/118/18/e2025167118. Acesso em: 2 jul. 2021. https://repositorio.ufrn.br/handle/123456789/32808 https://doi.org/10.1073/pnas.2025167118 en Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf
institution Repositório Institucional
collection RI - UFRN
language English
topic Cholesterol
LDLR
VSG G
Lentivirus
Viral transduction
spellingShingle Cholesterol
LDLR
VSG G
Lentivirus
Viral transduction
Velho, Tarciso André Ferreira
Lovell, Peter V
Friedrich, Samantha R
Olson, Christopher R
Miles, Joshua
Mueller, Paul A
Tavori, Hagai
Fazio, Sergio
Lois, Carlos
Mello, Claudio V
Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches
description The low-density lipoprotein receptor (LDLR) is key to cellular cholesterol uptake and is also the main receptor for the vesicular stomatitis virus glycoprotein (VSV G). Here we show that in songbirds LDLR is highly divergent and lacks domains critical for ligand binding and cellular trafficking, inconsistent with universal structure conservation and function across vertebrates. Linked to the LDLR functional domain loss, zebra finches show inefficient infectivity by lentiviruses (LVs) pseudotyped with VSV G, which can be rescued by the expression of human LDLR. Finches also show an atypical plasma lipid distribution that relies largely on high-density lipoprotein (HDL). These findings provide insights into the genetics and evolution of viral infectivity and cholesterol transport mechanisms in vertebrates
format article
author Velho, Tarciso André Ferreira
Lovell, Peter V
Friedrich, Samantha R
Olson, Christopher R
Miles, Joshua
Mueller, Paul A
Tavori, Hagai
Fazio, Sergio
Lois, Carlos
Mello, Claudio V
author_facet Velho, Tarciso André Ferreira
Lovell, Peter V
Friedrich, Samantha R
Olson, Christopher R
Miles, Joshua
Mueller, Paul A
Tavori, Hagai
Fazio, Sergio
Lois, Carlos
Mello, Claudio V
author_sort Velho, Tarciso André Ferreira
title Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches
title_short Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches
title_full Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches
title_fullStr Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches
title_full_unstemmed Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches
title_sort divergent low-density lipoprotein receptor (ldlr) linked to low vsv g-dependent viral infectivity and unique serum lipid profile in zebra finches
publishDate 2021
url https://repositorio.ufrn.br/handle/123456789/32808
https://doi.org/10.1073/pnas.2025167118
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