Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation

Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two reg...

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Principais autores: Almeida Filho, Daniel Gomes de, Koike, Bruna Del Vechio, Billwiller, Francesca, Farias, Kelly Soares, Sales, Igor Rafael Praxedes de, Luppi, Pierre-Hervé, Ribeiro, Sidarta Tollendal Gomes, Queiroz, Claudio Marcos Teixeira de
Formato: article
Idioma:English
Publicado em: Springer Science and Business Media LLC
Assuntos:
Hippocampus
Theta rhythm
Sleep, REM
Spatial learning
Gyrus cinguli
Endereço do item:https://repositorio.ufrn.br/handle/123456789/32768
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spelling ri-123456789-327682021-06-24T12:39:10Z Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation Almeida Filho, Daniel Gomes de Koike, Bruna Del Vechio Billwiller, Francesca Farias, Kelly Soares Sales, Igor Rafael Praxedes de Luppi, Pierre-Hervé Ribeiro, Sidarta Tollendal Gomes Queiroz, Claudio Marcos Teixeira de Hippocampus Theta rhythm Sleep, REM Spatial learning Gyrus cinguli Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta acceleration, in synchrony with phasic REM sleep. Altogether, these results support a role for phasic REM sleep in hippocampo-cortical memory consolidation and suggest that causality modulation between RSC and HPC during REM sleep plays a functional role in that phenomenon 2021-06-24T12:39:09Z 2021-06-24T12:39:09Z 2021-06-22 article ALMEIDA-FILHO, Daniel Gomes de; KOIKE, Bruna del Vechio; BILLWILLER, Francesca; FARIAS, Kelly Soares; SALES, Igor Rafael Praxedes de; LUPPI, Pierre-Hervé; RIBEIRO, Sidarta; QUEIROZ, Claudio Marcos. Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation. Scientific Reports, [S. l.], v. 11, n. 1, p. 13078. jun. 2021. Doi: http://dx.doi.org/10.1038/s41598-021-91659-5. Disponível em: https://www.nature.com/articles/s41598-021-91659-5. Acesso em: 24 jun. 2021. https://repositorio.ufrn.br/handle/123456789/32768 10.1038/s41598-021-91659-5 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Springer Science and Business Media LLC
institution Repositório Institucional
collection RI - UFRN
language English
topic Hippocampus
Theta rhythm
Sleep, REM
Spatial learning
Gyrus cinguli
spellingShingle Hippocampus
Theta rhythm
Sleep, REM
Spatial learning
Gyrus cinguli
Almeida Filho, Daniel Gomes de
Koike, Bruna Del Vechio
Billwiller, Francesca
Farias, Kelly Soares
Sales, Igor Rafael Praxedes de
Luppi, Pierre-Hervé
Ribeiro, Sidarta Tollendal Gomes
Queiroz, Claudio Marcos Teixeira de
Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
description Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta acceleration, in synchrony with phasic REM sleep. Altogether, these results support a role for phasic REM sleep in hippocampo-cortical memory consolidation and suggest that causality modulation between RSC and HPC during REM sleep plays a functional role in that phenomenon
format article
author Almeida Filho, Daniel Gomes de
Koike, Bruna Del Vechio
Billwiller, Francesca
Farias, Kelly Soares
Sales, Igor Rafael Praxedes de
Luppi, Pierre-Hervé
Ribeiro, Sidarta Tollendal Gomes
Queiroz, Claudio Marcos Teixeira de
author_facet Almeida Filho, Daniel Gomes de
Koike, Bruna Del Vechio
Billwiller, Francesca
Farias, Kelly Soares
Sales, Igor Rafael Praxedes de
Luppi, Pierre-Hervé
Ribeiro, Sidarta Tollendal Gomes
Queiroz, Claudio Marcos Teixeira de
author_sort Almeida Filho, Daniel Gomes de
title Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
title_short Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
title_full Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
title_fullStr Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
title_full_unstemmed Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
title_sort hippocampus-retrosplenial cortex interaction is increased during phasic rem and contributes to memory consolidation
publisher Springer Science and Business Media LLC
publishDate 2021
url https://repositorio.ufrn.br/handle/123456789/32768
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