Emulsão água-em-água como uma diferente abordagem para produção micropartículas à base de xilana contendo mesalazina
The water-in-water emulsion technique could be used to produce microparticles without using harmful solvents. However, there are few reports in the literature showing the encapsulation of low molecular weight drugs in microparticles using such technique. Therefore, the aim of this work was to dev...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/32612 |
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| Resumo: | The water-in-water emulsion technique could be used to produce microparticles without
using harmful solvents. However, there are few reports in the literature showing the
encapsulation of low molecular weight drugs in microparticles using such technique.
Therefore, the aim of this work was to develop ways to entrap drugs with low molecular
weight by means of the water-in-water emulsion technique using mesalazine as a
model drug. An approach using double crosslinking, with CaCl2, has been proposed to
promote higher encapsulation rates. For the production and choice of the best
microparticle formulation, a complete factorial design 23 and a phase diagram were
performed, respectively. The morphology of the particles and their mean diameter size
were evaluated by optical microscopy with a 10x amplitude. 500 particles were counted
in triplicate. For a better understanding of the chemical characteristics and interactions
among the drug, the crosslinkers and the polymer, infrared and X-ray diffractometry
(XRD) analyzes were carried out. In addition, the drug's release profile was assessed
using spectrophotometric readings over a 12-hour period. Among the formulations, the
average particle size varied between 4.6 ± 0.1 µm and 6.3 ± 0.2 µm. The results
revealed that all particles had spherical shape and non-aggregated microparticles were
found on the formulation. It was also noticed that when double crosslinking was used
in the production process, the encapsulation rate was higher when compared to the
formulation without this approach. This result was also observed by the infrared and
the XRD analyzes, both of which presented identity of specific functional groups of the
drug in the formulations where CaCl2 was used. In addition, this approach allowed the
mesalazine to be encapsulated at around 50%, a result not previously demonstrated
by low molecular weight molecules using this technique. Another notable result was the
retention of almost 40% of the drug content of the formulation, after 12 hours of
dissolution testing. This was probably due to the high degree of crosslinking of the
polymer. Therefore, the double crosslinking approach used to produce microparticles
was effective to entrap mesalazine and can be used as a new alternative to encapsulate
other molecules with similar physicochemical characteristics. |
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