Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch

Visceral leishmaniasis is an infecto-parasitarian disease caused by obligatory intracellular protozoa belonging to the genus Leishmania, and might be lethal since there is no precocious diagnosis and proper treatment. Despite the considerable effort, there is no effective and safe vaccine for human...

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Principais autores: Santos, Everaldo Silvino dos, Vaz, Michelle Rossana Ferreira, Sousa Junior, Francisco Canindé de, Padilha, Carlos Eduardo de Araújo, Martins, Daniella Regina Arantes, Macedo, Gorete Ribeiro
Formato: article
Idioma:English
Publicado em: BMC Proceedings
Assuntos:
Recombinant Protein
Lactose
Visceral Leishmaniasis
High Cell Density
Leishmaniasis
Endereço do item:https://repositorio.ufrn.br/handle/123456789/32541
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spelling ri-123456789-325412021-05-21T00:05:03Z Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch Santos, Everaldo Silvino dos Vaz, Michelle Rossana Ferreira Sousa Junior, Francisco Canindé de Padilha, Carlos Eduardo de Araújo Martins, Daniella Regina Arantes Macedo, Gorete Ribeiro Recombinant Protein Lactose Visceral Leishmaniasis High Cell Density Leishmaniasis Visceral leishmaniasis is an infecto-parasitarian disease caused by obligatory intracellular protozoa belonging to the genus Leishmania, and might be lethal since there is no precocious diagnosis and proper treatment. Despite the considerable effort, there is no effective and safe vaccine for human use [1]. Genetically modified micro-organisms are used industrially in general for production of hormone, antibiotics and proteins. In the production of heterologous molecules, both the expression and the production step are important [2]. Therefore, the study of cultivation conditions in bioreactor plays an important role for the process viability of batch and fed-batch [3]. Thus, the aim of this work was to study strategies for production of the 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch 2021-05-21T00:05:01Z 2021-05-21T00:05:01Z 2014-10-10 article VAZ, Michelle Rossana Ferreira; SOUSA JUNIOR, Francisco Canindé de; PADILHA, Carlos Eduardo de Araújo; MARTINS, Daniella Regina Arantes; SANTOS, Everaldo Silvino; MACEDO, Gorete Ribeiro. Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch. Bmc Proceedings, [S.L.], v. 8, n. 4, out. 2014. Disponível em: https://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-8-S4-P186. Acesso em: 08 abr 2021. http://dx.doi.org/10.1186/1753-6561-8-s4-p186. 1753-6561 https://repositorio.ufrn.br/handle/123456789/32541 10.1186/1753-6561-8-S4-P186 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf BMC Proceedings
institution Repositório Institucional
collection RI - UFRN
language English
topic Recombinant Protein
Lactose
Visceral Leishmaniasis
High Cell Density
Leishmaniasis
spellingShingle Recombinant Protein
Lactose
Visceral Leishmaniasis
High Cell Density
Leishmaniasis
Santos, Everaldo Silvino dos
Vaz, Michelle Rossana Ferreira
Sousa Junior, Francisco Canindé de
Padilha, Carlos Eduardo de Araújo
Martins, Daniella Regina Arantes
Macedo, Gorete Ribeiro
Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch
description Visceral leishmaniasis is an infecto-parasitarian disease caused by obligatory intracellular protozoa belonging to the genus Leishmania, and might be lethal since there is no precocious diagnosis and proper treatment. Despite the considerable effort, there is no effective and safe vaccine for human use [1]. Genetically modified micro-organisms are used industrially in general for production of hormone, antibiotics and proteins. In the production of heterologous molecules, both the expression and the production step are important [2]. Therefore, the study of cultivation conditions in bioreactor plays an important role for the process viability of batch and fed-batch [3]. Thus, the aim of this work was to study strategies for production of the 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch
format article
author Santos, Everaldo Silvino dos
Vaz, Michelle Rossana Ferreira
Sousa Junior, Francisco Canindé de
Padilha, Carlos Eduardo de Araújo
Martins, Daniella Regina Arantes
Macedo, Gorete Ribeiro
author_facet Santos, Everaldo Silvino dos
Vaz, Michelle Rossana Ferreira
Sousa Junior, Francisco Canindé de
Padilha, Carlos Eduardo de Araújo
Martins, Daniella Regina Arantes
Macedo, Gorete Ribeiro
author_sort Santos, Everaldo Silvino dos
title Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch
title_short Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch
title_full Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch
title_fullStr Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch
title_full_unstemmed Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch
title_sort production of recombinant 503 antigen of leishmania infantum chagasi using cultivation in batch and fed-batch
publisher BMC Proceedings
publishDate 2021
url https://repositorio.ufrn.br/handle/123456789/32541
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