Obtenção e caracterização de nanopartículas de quitosana e carboximetil-β-ciclodextrina contendo resveratrol
Chitosan (CS) and carboxymethyl-β-cyclodextrin (CM-β-CD) nanoparticles were obtained spontaneously by the attraction between molecules of opposite charge. CS is a biodegradable cationic polyelectrolyte capable of interacting and forming polyelectrolytic complexes with CM-β-CD, modified anionic cy...
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| Formato: | doctoralThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/32519 |
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| Resumo: | Chitosan (CS) and carboxymethyl-β-cyclodextrin (CM-β-CD) nanoparticles were obtained
spontaneously by the attraction between molecules of opposite charge. CS is a biodegradable
cationic polyelectrolyte capable of interacting and forming polyelectrolytic complexes with
CM-β-CD, modified anionic cyclodextrin. Resveratrol (RES), a polyphenol with excellent
pharmaceutical properties, was incorporated into this system and characterized. The parameter
that changed in this study was the ratio (r) between the carboxylate groups of CM-β-CD and
the amino groups of CS, with molar ratio between 0.23 and 0.45. CM-β-CD was synthesized
from β-CD and characterized by XRD, FTIR and TG / DTG that confirmed the successful
chemical modification. The obtained CM-β-CD had a degree of substitution of 5, with a molar
mass of 1446 g/mol by Maldi TOF. Through the physical-chemical characterization it was
possible to verify the formation of nanoparticles of CS/CM-β-CD, which had a spherical shape
and particle size ranging from 100 to 400 nm, while with the RES the diameter was around 160
nm. Regarding thermal analysis, it was observed that the increase in temperature did not favor
the maintenance of the complexes between CS/CM-β-CD and CS/CM-β-CD with RES. The
ITC study was carried out to assess physical-chemical parameters of intermolecular
interactions, between CS, CDs (β-CD and CM-β-CD) and RES. Regarding the affinity between
RES and the cyclodextrins, a greater complexing capacity was observed between RES and the
anionic CD, suggesting that the complexes formed are more stable, with a 2:1 stoichiometry
(CD / RES). |
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