Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid

The purpose of this study was to extract alkaloids from Melocactus zehntneri aerial parts using supercrit-ical fluid extraction (SFE) and to evaluate their cytotoxic action. SFE process was compared to differentclassical low pressure solvent extraction processes in terms of global yield, extract pro...

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Principais autores: Brandão, Gustavo Henrique Azevedo, Rigo, Graziela Vargas, Roque, A. A., Souza, A. C. D., Scopel, Marina, Nascimento, Cláudio Augusto Oller do, Tasca, Tiana, Courtial, Camila Gambini Pereira, Giordani, Raquel Brandt
Formato: article
Idioma:English
Publicado em: Elsevier
Assuntos:
Melocactus zehntneri
Alkaloids
Supercritical fluids
Trichomonas vaginalis
HMVIIa
Endereço do item:https://repositorio.ufrn.br/handle/123456789/32508
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spelling ri-123456789-325082021-11-19T16:52:32Z Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid Brandão, Gustavo Henrique Azevedo Rigo, Graziela Vargas Roque, A. A. Souza, A. C. D. Scopel, Marina Nascimento, Cláudio Augusto Oller do Tasca, Tiana Courtial, Camila Gambini Pereira Giordani, Raquel Brandt Melocactus zehntneri Alkaloids Supercritical fluids Trichomonas vaginalis HMVIIa The purpose of this study was to extract alkaloids from Melocactus zehntneri aerial parts using supercrit-ical fluid extraction (SFE) and to evaluate their cytotoxic action. SFE process was compared to differentclassical low pressure solvent extraction processes in terms of global yield, extract profile and biologicalactivity. Two specimens of M. zehntneri were evaluated: young and adult aerial parts. The extracts wereanalyzed by HPLC-UV/DAD as well as they were evaluated against HMVII and Trichomonas vaginalis. Theresults indicated a qualitative difference in chromatographic profile of the extracts. Finally, the resultspoint out the potential of the extract obtained from aerial parts of young specimens (Y-RM) through SFEat 300 bar/55◦C against T. vaginalis and HMVII, presenting relevant information for development of newstudies about cytotoxic 2021-05-12T18:14:08Z 2021-05-12T18:14:08Z 2017-11 article BRANDÃO, G.H.A.; RIGO, G.; ROQUE, A.A.; SOUZA, A.C.D.; SCOPEL, M.; NASCIMENTO, C.A.O.; TASCA, T.; PEREIRA, C.G.; GIORDANI, R.B. . Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid. JOURNAL OF SUPERCRITICAL FLUIDS, v. 129, p. 28-35, 2017. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0896844616305630?via%3Dihub. Acesso em: 05 abr. 2021. https://doi.org/10.1016/j.supflu.2016.12.012 0896-8446 https://repositorio.ufrn.br/handle/123456789/32508 10.1016/j.supflu.2016.12.012 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Elsevier
institution Repositório Institucional
collection RI - UFRN
language English
topic Melocactus zehntneri
Alkaloids
Supercritical fluids
Trichomonas vaginalis
HMVIIa
spellingShingle Melocactus zehntneri
Alkaloids
Supercritical fluids
Trichomonas vaginalis
HMVIIa
Brandão, Gustavo Henrique Azevedo
Rigo, Graziela Vargas
Roque, A. A.
Souza, A. C. D.
Scopel, Marina
Nascimento, Cláudio Augusto Oller do
Tasca, Tiana
Courtial, Camila Gambini Pereira
Giordani, Raquel Brandt
Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
description The purpose of this study was to extract alkaloids from Melocactus zehntneri aerial parts using supercrit-ical fluid extraction (SFE) and to evaluate their cytotoxic action. SFE process was compared to differentclassical low pressure solvent extraction processes in terms of global yield, extract profile and biologicalactivity. Two specimens of M. zehntneri were evaluated: young and adult aerial parts. The extracts wereanalyzed by HPLC-UV/DAD as well as they were evaluated against HMVII and Trichomonas vaginalis. Theresults indicated a qualitative difference in chromatographic profile of the extracts. Finally, the resultspoint out the potential of the extract obtained from aerial parts of young specimens (Y-RM) through SFEat 300 bar/55◦C against T. vaginalis and HMVII, presenting relevant information for development of newstudies about cytotoxic
format article
author Brandão, Gustavo Henrique Azevedo
Rigo, Graziela Vargas
Roque, A. A.
Souza, A. C. D.
Scopel, Marina
Nascimento, Cláudio Augusto Oller do
Tasca, Tiana
Courtial, Camila Gambini Pereira
Giordani, Raquel Brandt
author_facet Brandão, Gustavo Henrique Azevedo
Rigo, Graziela Vargas
Roque, A. A.
Souza, A. C. D.
Scopel, Marina
Nascimento, Cláudio Augusto Oller do
Tasca, Tiana
Courtial, Camila Gambini Pereira
Giordani, Raquel Brandt
author_sort Brandão, Gustavo Henrique Azevedo
title Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
title_short Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
title_full Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
title_fullStr Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
title_full_unstemmed Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
title_sort extraction of bioactive alkaloids from melocactus zehntneri using supercritical fluid
publisher Elsevier
publishDate 2021
url https://repositorio.ufrn.br/handle/123456789/32508
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