Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial

Background: the preemptive use of anti-inflammatory drugs, such as corticosteroids and NSAIDs, has the potential to reduce pain, swelling and trismus following oral surgery. The aim of this study was to compare the efficacy of dexamethasone and ketorolac tromethamine in reducing pain, swelling and t...

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Principais autores: Martins-de-Barros, Allan Vinícius, Barros, Ana Maria Ipólito, Siqueira, Anna Karolline Cadengue de, Lucena, Eudes Euler de Souza, Sette-de-Souza, Pedro Henrique, Araújo, Fábio Andrey da Costa
Formato: article
Idioma:English
Publicado em: Medicina Oral S.L
Assuntos:
Third Molar
Anti-inflammatory agents
Dexamethasone
Ketorolac
Endereço do item:https://repositorio.ufrn.br/handle/123456789/32110
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spelling ri-123456789-321102021-04-11T09:06:29Z Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial Martins-de-Barros, Allan Vinícius Barros, Ana Maria Ipólito Siqueira, Anna Karolline Cadengue de Lucena, Eudes Euler de Souza Sette-de-Souza, Pedro Henrique Araújo, Fábio Andrey da Costa Third Molar Anti-inflammatory agents Dexamethasone Ketorolac Background: the preemptive use of anti-inflammatory drugs, such as corticosteroids and NSAIDs, has the potential to reduce pain, swelling and trismus following oral surgery. The aim of this study was to compare the efficacy of dexamethasone and ketorolac tromethamine in reducing pain, swelling and trismus after mandibular third molar removal. Material and Methods: the researches implemented a triple-blind, randomized clinical trial. The study was conducted with ASA I individuals aging between 18 and 35 years, which were randomized and submitted to two interventions, one with 8mg dexamethasone and the other with 20mg ketorolac tromethamine given 1h before the procedure. The primary predictor variable was the use of dexamethasone or ketorolac. The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale. The secondary outcome variables were the amount of rescue analgesic consumed, swelling and trismus. Repeated-measures ANOVA and t-test for paired samples were used to compare the means. Significance was set at p < 0.05. Results: fifty individuals were randomized and allocated to intervention, and the sample was composed of 40 subjects who completed the study (27 female and 13 male). Dexamethasone, when compared to ketorolac tromethamine, showed a significantly higher reduction in pain level at 8h, 16h, 24h, 32h, 40h and 72h, in swelling and trismus at 24h, 48h, 72h and 7 days and in total number of rescue analgesics taken up to 72h postoperative (p < 0.05). Conclusions: the clinical performance of dexamethasone in controlling pain, swelling and trismus after mandibular third molar removal was superior to ketorolac tromethamine’s 2021-04-08T10:32:38Z 2021-04-08T10:32:38Z 2020 article MARTINS-DE-BARROS, Allan Vinícius; BARROS, Ana Maria Ipólito; SIQUEIRA, Anna Karolline Cadengue de; LUCENA, Eudes Euler de Souza; SETTE-DE-SOUZA, Pedro Henrique; ARAÚJO, Fábio Andrey da Costa. Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. Medicina Oral Patologia Oral y Cirugia Bucal, [s. l.], v. 28, p. 141-150, 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33247572/#:~:text=Conclusions%3A%20The%20clinical%20performance%20of,was%20superior%20to%20ketorolac%20tromethamine's. Acesso em: 08 mar. 2021. http://dx.doi.org/10.4317/medoral.24088. 1698-4447 1698-6946 https://repositorio.ufrn.br/handle/123456789/32110 10.4317/medoral.24088 en application/pdf Medicina Oral S.L
institution Repositório Institucional
collection RI - UFRN
language English
topic Third Molar
Anti-inflammatory agents
Dexamethasone
Ketorolac
spellingShingle Third Molar
Anti-inflammatory agents
Dexamethasone
Ketorolac
Martins-de-Barros, Allan Vinícius
Barros, Ana Maria Ipólito
Siqueira, Anna Karolline Cadengue de
Lucena, Eudes Euler de Souza
Sette-de-Souza, Pedro Henrique
Araújo, Fábio Andrey da Costa
Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial
description Background: the preemptive use of anti-inflammatory drugs, such as corticosteroids and NSAIDs, has the potential to reduce pain, swelling and trismus following oral surgery. The aim of this study was to compare the efficacy of dexamethasone and ketorolac tromethamine in reducing pain, swelling and trismus after mandibular third molar removal. Material and Methods: the researches implemented a triple-blind, randomized clinical trial. The study was conducted with ASA I individuals aging between 18 and 35 years, which were randomized and submitted to two interventions, one with 8mg dexamethasone and the other with 20mg ketorolac tromethamine given 1h before the procedure. The primary predictor variable was the use of dexamethasone or ketorolac. The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale. The secondary outcome variables were the amount of rescue analgesic consumed, swelling and trismus. Repeated-measures ANOVA and t-test for paired samples were used to compare the means. Significance was set at p < 0.05. Results: fifty individuals were randomized and allocated to intervention, and the sample was composed of 40 subjects who completed the study (27 female and 13 male). Dexamethasone, when compared to ketorolac tromethamine, showed a significantly higher reduction in pain level at 8h, 16h, 24h, 32h, 40h and 72h, in swelling and trismus at 24h, 48h, 72h and 7 days and in total number of rescue analgesics taken up to 72h postoperative (p < 0.05). Conclusions: the clinical performance of dexamethasone in controlling pain, swelling and trismus after mandibular third molar removal was superior to ketorolac tromethamine’s
format article
author Martins-de-Barros, Allan Vinícius
Barros, Ana Maria Ipólito
Siqueira, Anna Karolline Cadengue de
Lucena, Eudes Euler de Souza
Sette-de-Souza, Pedro Henrique
Araújo, Fábio Andrey da Costa
author_facet Martins-de-Barros, Allan Vinícius
Barros, Ana Maria Ipólito
Siqueira, Anna Karolline Cadengue de
Lucena, Eudes Euler de Souza
Sette-de-Souza, Pedro Henrique
Araújo, Fábio Andrey da Costa
author_sort Martins-de-Barros, Allan Vinícius
title Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial
title_short Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial
title_full Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial
title_fullStr Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial
title_full_unstemmed Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial
title_sort is dexamethasone superior to ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? a split mouth triple-blind randomized clinical trial
publisher Medicina Oral S.L
publishDate 2021
url https://repositorio.ufrn.br/handle/123456789/32110
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