Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival
Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or p...
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ri-123456789-320282022-04-08T14:28:12Z Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival Archanjo, Anderson Barros Assis, Arícia Leone Evangelista Monteiro de Oliveira, Mayara Mota de Mendes, Suzanny Oliveira Borçoi, Aline Ribeiro Maia, Lucas de Lima Souza, Rafael Pereira de Cicco, Rafael de Saito, Kelly Cristina Kimura, Edna Teruko Carvalho, Marcos Brasilino de Nunes, Fabio Daumas Tajara, Eloiza H. Santos, Marcelo dos Nogueira, Breno Valentim Trivilin, Leonardo Oliveira Pinheiro, Christiano Jorge Gomes Silva, Adriana Madeira Álvares da Tobacco use disorder Smoke Carcinoma, Squamous cell Tumor cells, Cultured Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. We found the presence of magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, zinc, cobalt, nickel, copper, arsenic and bromine in OCSCC samples. Magnesium, chlorine, chromium, manganese, nickel, arsenic and bromine are associated with smoking. We observed a significant association between relapse and chlorine and chromium. The presence of chlorine in the samples was an independent protective factor against relapse (OR = 0.105, CI = 0.01–0.63) and for best disease-free survival (HR = 0.194, CI = 0.04–0.87). Reporting for the first time in oral cancer, these results suggest a key relationship between smoking and the presence of certain elements. In addition, chlorine proved to be important in the context of patient prognosis and survival 2021-03-31T10:38:14Z 2021-03-31T10:38:14Z 2020-06-25 article ARCHANJO, Anderson Barros et al. Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival. Scientific Reports, [s. l.], v. 10, n. 1, p. 1-10, 25 jun. 2020. Springer Science and Business Media LLC. Disponível em: https://www.nature.com/articles/s41598-020-67270-5. Acesso em: 30 mar. 2021. http://dx.doi.org/10.1038/s41598-020-67270-5 2045-2322 (online) https://repositorio.ufrn.br/handle/123456789/32028 10.1038/s41598-020-67270-5 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Nature Research |
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Tobacco use disorder Smoke Carcinoma, Squamous cell Tumor cells, Cultured |
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Tobacco use disorder Smoke Carcinoma, Squamous cell Tumor cells, Cultured Archanjo, Anderson Barros Assis, Arícia Leone Evangelista Monteiro de Oliveira, Mayara Mota de Mendes, Suzanny Oliveira Borçoi, Aline Ribeiro Maia, Lucas de Lima Souza, Rafael Pereira de Cicco, Rafael de Saito, Kelly Cristina Kimura, Edna Teruko Carvalho, Marcos Brasilino de Nunes, Fabio Daumas Tajara, Eloiza H. Santos, Marcelo dos Nogueira, Breno Valentim Trivilin, Leonardo Oliveira Pinheiro, Christiano Jorge Gomes Silva, Adriana Madeira Álvares da Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival |
description |
Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. We found the presence of magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, zinc, cobalt, nickel, copper, arsenic and bromine in OCSCC samples. Magnesium, chlorine, chromium, manganese, nickel, arsenic and bromine are associated with smoking. We observed a significant association between relapse and chlorine and chromium. The presence of chlorine in the samples was an independent protective factor against relapse (OR = 0.105, CI = 0.01–0.63) and for best disease-free survival (HR = 0.194, CI = 0.04–0.87). Reporting for the first time in oral cancer, these results suggest a key relationship between smoking and the presence of certain elements. In addition, chlorine proved to be important in the context of patient prognosis and survival |
format |
article |
author |
Archanjo, Anderson Barros Assis, Arícia Leone Evangelista Monteiro de Oliveira, Mayara Mota de Mendes, Suzanny Oliveira Borçoi, Aline Ribeiro Maia, Lucas de Lima Souza, Rafael Pereira de Cicco, Rafael de Saito, Kelly Cristina Kimura, Edna Teruko Carvalho, Marcos Brasilino de Nunes, Fabio Daumas Tajara, Eloiza H. Santos, Marcelo dos Nogueira, Breno Valentim Trivilin, Leonardo Oliveira Pinheiro, Christiano Jorge Gomes Silva, Adriana Madeira Álvares da |
author_facet |
Archanjo, Anderson Barros Assis, Arícia Leone Evangelista Monteiro de Oliveira, Mayara Mota de Mendes, Suzanny Oliveira Borçoi, Aline Ribeiro Maia, Lucas de Lima Souza, Rafael Pereira de Cicco, Rafael de Saito, Kelly Cristina Kimura, Edna Teruko Carvalho, Marcos Brasilino de Nunes, Fabio Daumas Tajara, Eloiza H. Santos, Marcelo dos Nogueira, Breno Valentim Trivilin, Leonardo Oliveira Pinheiro, Christiano Jorge Gomes Silva, Adriana Madeira Álvares da |
author_sort |
Archanjo, Anderson Barros |
title |
Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival |
title_short |
Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival |
title_full |
Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival |
title_fullStr |
Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival |
title_full_unstemmed |
Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival |
title_sort |
elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival |
publisher |
Nature Research |
publishDate |
2021 |
url |
https://repositorio.ufrn.br/handle/123456789/32028 |
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