Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival

Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or p...

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Detalhes bibliográficos
Principais autores: Archanjo, Anderson Barros, Assis, Arícia Leone Evangelista Monteiro de, Oliveira, Mayara Mota de, Mendes, Suzanny Oliveira, Borçoi, Aline Ribeiro, Maia, Lucas de Lima, Souza, Rafael Pereira de, Cicco, Rafael de, Saito, Kelly Cristina, Kimura, Edna Teruko, Carvalho, Marcos Brasilino de, Nunes, Fabio Daumas, Tajara, Eloiza H., Santos, Marcelo dos, Nogueira, Breno Valentim, Trivilin, Leonardo Oliveira, Pinheiro, Christiano Jorge Gomes, Silva, Adriana Madeira Álvares da
Formato: article
Idioma:English
Publicado em: Nature Research
Assuntos:
Tobacco use disorder
Smoke
Carcinoma, Squamous cell
Tumor cells, Cultured
Endereço do item:https://repositorio.ufrn.br/handle/123456789/32028
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Resumo:Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. We found the presence of magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, zinc, cobalt, nickel, copper, arsenic and bromine in OCSCC samples. Magnesium, chlorine, chromium, manganese, nickel, arsenic and bromine are associated with smoking. We observed a significant association between relapse and chlorine and chromium. The presence of chlorine in the samples was an independent protective factor against relapse (OR = 0.105, CI = 0.01–0.63) and for best disease-free survival (HR = 0.194, CI = 0.04–0.87). Reporting for the first time in oral cancer, these results suggest a key relationship between smoking and the presence of certain elements. In addition, chlorine proved to be important in the context of patient prognosis and survival

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