Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography

Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women. Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations,...

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Principais autores: Souza Júnior, José Edvan de, Garcia, Carlos Alexandre de Amorim, Soares, Elvira Maria Mafaldo, Maranhão, Técia Maria Oliveira, Lemos, Telma Maria Araujo Moura, Azevedo, George Dantas de
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Idioma:English
Publicado em: Hindawi
Assuntos:
Polycystic Ovary Syndrome
Optical Coherence Tomography
Ophthalmology
Macular Thickness
Retinal Nerve Fiber Layers
Endereço do item:https://repositorio.ufrn.br/handle/123456789/31564
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spelling ri-123456789-315642021-02-21T08:32:25Z Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography Souza Júnior, José Edvan de Garcia, Carlos Alexandre de Amorim Soares, Elvira Maria Mafaldo Maranhão, Técia Maria Oliveira Lemos, Telma Maria Araujo Moura Azevedo, George Dantas de Polycystic Ovary Syndrome Optical Coherence Tomography Ophthalmology Macular Thickness Retinal Nerve Fiber Layers Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women. Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measurement of MT, RNFL, and optic disc parameters using optical coherence tomography. Results. The superior RNFL around the optic nerve was significantly thicker in PCOS than in healthy volunteers ( = 0.036). After stratification according to insulin resistance, the temporal inner macula (TIM), the inferior inner macula (IIM), the nasal inner macula (NIM), and the nasal outer macula (NOM) were significantly thicker in PCOS group than in control group ( < 0.05). Both the presence of obesity associated with insulin resistance ( = 0.037) and glucose intolerance ( = 0.001) were associated with significant increase in the PC1 mean score, relative to MT. A significant increase in the PC2 mean score occurred when considering the presence of metabolic syndrome ( < 0.0001). There was a significant interaction between obesity and inflammation in a decreasing mean PC2 score relative to macular RNFL thickness ( = 0.034). Conclusion. Decreased macular RNFL thickness and increased total MT are associated with metabolic abnormalities, while increased RNFL thickness around the optic nerve is associated with hormonal changes inherent in PCOS 2021-02-19T17:02:20Z 2021-02-19T17:02:20Z 2015-02-11 article SOUZA JÚNIOR, José Edvan de; GARCIA, Carlos Alexandre de Amorim; SOARES, Elvira Maria Mafaldo; MARANHÃO, Técia Maria Oliveira; LEMOS, Telma Maria Araújo Moura; AZEVEDO, George Dantas de. Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography. Journal Of Ophthalmology, [s. l.], v. 2015, p. 1-8, 2015. Disponível em: https://www.hindawi.com/journals/joph/2015/193078/. Acesso em: 30 jun. 2020. http://dx.doi.org/10.1155/2015/193078 2090-004X 2090-0058 https://repositorio.ufrn.br/handle/123456789/31564 10.1155/2015/193078 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Hindawi
institution Repositório Institucional
collection RI - UFRN
language English
topic Polycystic Ovary Syndrome
Optical Coherence Tomography
Ophthalmology
Macular Thickness
Retinal Nerve Fiber Layers
spellingShingle Polycystic Ovary Syndrome
Optical Coherence Tomography
Ophthalmology
Macular Thickness
Retinal Nerve Fiber Layers
Souza Júnior, José Edvan de
Garcia, Carlos Alexandre de Amorim
Soares, Elvira Maria Mafaldo
Maranhão, Técia Maria Oliveira
Lemos, Telma Maria Araujo Moura
Azevedo, George Dantas de
Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography
description Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women. Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measurement of MT, RNFL, and optic disc parameters using optical coherence tomography. Results. The superior RNFL around the optic nerve was significantly thicker in PCOS than in healthy volunteers ( = 0.036). After stratification according to insulin resistance, the temporal inner macula (TIM), the inferior inner macula (IIM), the nasal inner macula (NIM), and the nasal outer macula (NOM) were significantly thicker in PCOS group than in control group ( < 0.05). Both the presence of obesity associated with insulin resistance ( = 0.037) and glucose intolerance ( = 0.001) were associated with significant increase in the PC1 mean score, relative to MT. A significant increase in the PC2 mean score occurred when considering the presence of metabolic syndrome ( < 0.0001). There was a significant interaction between obesity and inflammation in a decreasing mean PC2 score relative to macular RNFL thickness ( = 0.034). Conclusion. Decreased macular RNFL thickness and increased total MT are associated with metabolic abnormalities, while increased RNFL thickness around the optic nerve is associated with hormonal changes inherent in PCOS
format article
author Souza Júnior, José Edvan de
Garcia, Carlos Alexandre de Amorim
Soares, Elvira Maria Mafaldo
Maranhão, Técia Maria Oliveira
Lemos, Telma Maria Araujo Moura
Azevedo, George Dantas de
author_facet Souza Júnior, José Edvan de
Garcia, Carlos Alexandre de Amorim
Soares, Elvira Maria Mafaldo
Maranhão, Técia Maria Oliveira
Lemos, Telma Maria Araujo Moura
Azevedo, George Dantas de
author_sort Souza Júnior, José Edvan de
title Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography
title_short Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography
title_full Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography
title_fullStr Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography
title_full_unstemmed Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography
title_sort polycystic ovary syndrome: aggressive or protective factor for the retina? evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography
publisher Hindawi
publishDate 2021
url https://repositorio.ufrn.br/handle/123456789/31564
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