Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome

Aims: we aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: a study was conducted in Natal, RN, Brazil selecti...

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Principais autores: Soares, Nayara Pereira, Santos, Ana Celly Souza dos, Costa, Eduardo Caldas, Azevedo, George Dantas de, Damasceno, Débora Cristina, Fayh, Ana Paula Trussardi, Lemos, Telma Maria Araujo Moura
Formato: article
Idioma:English
Publicado em: Karger Publishers
Assuntos:
Diet
DNA damage
Cardiometabolic risk factors
Overweight
Obesity
Polycystic ovary syndrome
Endereço do item:https://repositorio.ufrn.br/handle/123456789/31563
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spelling ri-123456789-315632021-02-21T08:32:02Z Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome Soares, Nayara Pereira Santos, Ana Celly Souza dos Costa, Eduardo Caldas Azevedo, George Dantas de Damasceno, Débora Cristina Fayh, Ana Paula Trussardi Lemos, Telma Maria Araujo Moura Diet DNA damage Cardiometabolic risk factors Overweight Obesity Polycystic ovary syndrome Aims: we aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: a study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index ≥25 and <39 kg/m2) women (18-35 years). The levels of DNA damage were assessed by a single cell gel electrophoresis. Repeated 24 h dietary recall questionnaires, anthropometry, biochemical profile and sex hormones were collected at baseline and after 12 weeks of intervention. Results: Women exhibiting a decrease in the markers of DNA damage: tail intensity (24.35 ± 5.86 - pre diet vs. 17.15 ± 5.04 - post-diet; p < 0.001) and tail moment (20.47 ± 7.85 - pre diet vs. 14.13 ± 6.29 - post-diet; p < 0.002). Reduction of calorie intake, weight loss, decreased sexual hormone and cardiometabolic markers such as insulin, homeostasis model assessment of insulin resistance and low-density lipoprotein cholesterol were verified In the multivariate regression analysis, quantitative insulin sensitivity check index and progesterone were responsible for the variation markers in DNA damage before the diet, losing its influence upon diet. Conclusion: DNA damage and the impact of cardiometabolic risk factors decreased after the intervention in women with PCOS, indicating the relevance of a nutritional approach in this group of patients 2021-02-19T16:38:07Z 2021-02-19T16:38:07Z 2016-04-14 article SOARES, Nayara Pereira; SANTOS, Ana Celly Souza dos; COSTA, Eduardo Caldas; AZEVEDO, George Dantas de; DAMASCENO, Débora Cristina; FAYH, Ana Paula Trussardi; LEMOS, Telma Maria Araújo Moura. Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome. Annals Of Nutrition And Metabolism, [s. l.], v. 68, n. 3, p. 220-227, 2016. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27073909/. Acesso em: 18 fev. 2021. http://dx.doi.org/10.1159/000444130 0250-6807 1421-9697 10.1159/000444130 https://repositorio.ufrn.br/handle/123456789/31563 en Attribution-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nd/3.0/br/ application/pdf Karger Publishers
institution Repositório Institucional
collection RI - UFRN
language English
topic Diet
DNA damage
Cardiometabolic risk factors
Overweight
Obesity
Polycystic ovary syndrome
spellingShingle Diet
DNA damage
Cardiometabolic risk factors
Overweight
Obesity
Polycystic ovary syndrome
Soares, Nayara Pereira
Santos, Ana Celly Souza dos
Costa, Eduardo Caldas
Azevedo, George Dantas de
Damasceno, Débora Cristina
Fayh, Ana Paula Trussardi
Lemos, Telma Maria Araujo Moura
Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome
description Aims: we aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: a study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index ≥25 and <39 kg/m2) women (18-35 years). The levels of DNA damage were assessed by a single cell gel electrophoresis. Repeated 24 h dietary recall questionnaires, anthropometry, biochemical profile and sex hormones were collected at baseline and after 12 weeks of intervention. Results: Women exhibiting a decrease in the markers of DNA damage: tail intensity (24.35 ± 5.86 - pre diet vs. 17.15 ± 5.04 - post-diet; p < 0.001) and tail moment (20.47 ± 7.85 - pre diet vs. 14.13 ± 6.29 - post-diet; p < 0.002). Reduction of calorie intake, weight loss, decreased sexual hormone and cardiometabolic markers such as insulin, homeostasis model assessment of insulin resistance and low-density lipoprotein cholesterol were verified In the multivariate regression analysis, quantitative insulin sensitivity check index and progesterone were responsible for the variation markers in DNA damage before the diet, losing its influence upon diet. Conclusion: DNA damage and the impact of cardiometabolic risk factors decreased after the intervention in women with PCOS, indicating the relevance of a nutritional approach in this group of patients
format article
author Soares, Nayara Pereira
Santos, Ana Celly Souza dos
Costa, Eduardo Caldas
Azevedo, George Dantas de
Damasceno, Débora Cristina
Fayh, Ana Paula Trussardi
Lemos, Telma Maria Araujo Moura
author_facet Soares, Nayara Pereira
Santos, Ana Celly Souza dos
Costa, Eduardo Caldas
Azevedo, George Dantas de
Damasceno, Débora Cristina
Fayh, Ana Paula Trussardi
Lemos, Telma Maria Araujo Moura
author_sort Soares, Nayara Pereira
title Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome
title_short Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome
title_full Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome
title_fullStr Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome
title_full_unstemmed Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome
title_sort diet-induced weight loss reduces dna damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome
publisher Karger Publishers
publishDate 2021
url https://repositorio.ufrn.br/handle/123456789/31563
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