Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells

Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated L-fucose. Heterofucan SF-1.5v was extracted from the brown seaweed Sargassum filipendula by proteolytic digestion followed by sequential acetone precipitation. This fucan showed antiproliferative activity on Hel...

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Principais autores:	Costa, Leandro Silva, Telles, Cinthia Beatrice Silva, Oliveira, Ruth Medeiros, Nobre, Leonardo Thiago Duarte Barreto, Dantas-Santos, Nednaldo, Câmara, Rafael Barros Gomes da, Costa, Mariana Santana Santos Pereira, Almeida-Lima, Jailma, Melo-Silveira, Raniere Fagundes, Albuquerque, Ivan Rui Lopes, Leite, Edda Lisboa, Rocha, Hugo Alexandre de Oliveira
Formato:	article
Idioma:	English
Publicado em:	MDPI
Assuntos:	Fucoidan Sulfated polysaccharides Anticancer Apoptosis-inducing factor (AIF)
Endereço do item:	https://repositorio.ufrn.br/handle/123456789/31327
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spelling	ri-123456789-313272021-01-31T08:19:41Z Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells Costa, Leandro Silva Telles, Cinthia Beatrice Silva Oliveira, Ruth Medeiros Nobre, Leonardo Thiago Duarte Barreto Dantas-Santos, Nednaldo Câmara, Rafael Barros Gomes da Costa, Mariana Santana Santos Pereira Almeida-Lima, Jailma Melo-Silveira, Raniere Fagundes Albuquerque, Ivan Rui Lopes Leite, Edda Lisboa Rocha, Hugo Alexandre de Oliveira Fucoidan Sulfated polysaccharides Anticancer Apoptosis-inducing factor (AIF) Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated L-fucose. Heterofucan SF-1.5v was extracted from the brown seaweed Sargassum filipendula by proteolytic digestion followed by sequential acetone precipitation. This fucan showed antiproliferative activity on Hela cells and induced apoptosis. However, SF-1.5v was not able to activate caspases. Moreover, SF-1.5v induced glycogen synthase kinase (GSK) activation, but this protein is not involved in the heterofucan SF-1.5v induced apoptosis mechanism. In addition, ERK, p38, p53, pAKT and NFκB were not affected by the presence of SF-1.5v. We determined that SF-1.5v induces apoptosis in HeLa mainly by mitochondrial release of apoptosis-inducing factor (AIF) into cytosol. In addition, SF-1.5v decreases the expression of anti-apoptotic protein Bcl-2 and increased expression of apoptogenic protein Bax. These results are significant in that they provide a mechanistic framework for further exploring the use of SF-1.5v as a novel chemotherapeutics against human cervical cancer 2021-01-29T18:31:11Z 2021-01-29T18:31:11Z 2011-04-14 article COSTA, Leandro Silva; TELLES, Cinthia Beatrice Silva; OLIVEIRA, Ruth Medeiros; NOBRE, Leonardo Thiago Duarte Barreto; DANTAS-SANTOS, Nednaldo; CAMARA, Rafael Barros Gomes da; COSTA, Mariana Santana Santos Pereira; ALMEIDA-LIMA, Jailma; MELO-SILVEIRA, Raniere Fagundes; ALBUQUERQUE, Ivan Rui Lopes. Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells. Marine Drugs, [s. l.], v. 9, n. 4, p. 603-614, 14 abr. 2011. MDPI AG. http://dx.doi.org/10.3390/md9040603. Disponível em: https://www.mdpi.com/1660-3397/9/4/603. Acesso em: 16 set. 2020. 1660-3397 (online) https://repositorio.ufrn.br/handle/123456789/31327 10.3390/md9040603 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf MDPI
institution	Repositório Institucional
collection	RI - UFRN
language	English
topic	Fucoidan Sulfated polysaccharides Anticancer Apoptosis-inducing factor (AIF)
spellingShingle	Fucoidan Sulfated polysaccharides Anticancer Apoptosis-inducing factor (AIF) Costa, Leandro Silva Telles, Cinthia Beatrice Silva Oliveira, Ruth Medeiros Nobre, Leonardo Thiago Duarte Barreto Dantas-Santos, Nednaldo Câmara, Rafael Barros Gomes da Costa, Mariana Santana Santos Pereira Almeida-Lima, Jailma Melo-Silveira, Raniere Fagundes Albuquerque, Ivan Rui Lopes Leite, Edda Lisboa Rocha, Hugo Alexandre de Oliveira Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells
description	Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated L-fucose. Heterofucan SF-1.5v was extracted from the brown seaweed Sargassum filipendula by proteolytic digestion followed by sequential acetone precipitation. This fucan showed antiproliferative activity on Hela cells and induced apoptosis. However, SF-1.5v was not able to activate caspases. Moreover, SF-1.5v induced glycogen synthase kinase (GSK) activation, but this protein is not involved in the heterofucan SF-1.5v induced apoptosis mechanism. In addition, ERK, p38, p53, pAKT and NFκB were not affected by the presence of SF-1.5v. We determined that SF-1.5v induces apoptosis in HeLa mainly by mitochondrial release of apoptosis-inducing factor (AIF) into cytosol. In addition, SF-1.5v decreases the expression of anti-apoptotic protein Bcl-2 and increased expression of apoptogenic protein Bax. These results are significant in that they provide a mechanistic framework for further exploring the use of SF-1.5v as a novel chemotherapeutics against human cervical cancer
format	article
author	Costa, Leandro Silva Telles, Cinthia Beatrice Silva Oliveira, Ruth Medeiros Nobre, Leonardo Thiago Duarte Barreto Dantas-Santos, Nednaldo Câmara, Rafael Barros Gomes da Costa, Mariana Santana Santos Pereira Almeida-Lima, Jailma Melo-Silveira, Raniere Fagundes Albuquerque, Ivan Rui Lopes Leite, Edda Lisboa Rocha, Hugo Alexandre de Oliveira
author_facet	Costa, Leandro Silva Telles, Cinthia Beatrice Silva Oliveira, Ruth Medeiros Nobre, Leonardo Thiago Duarte Barreto Dantas-Santos, Nednaldo Câmara, Rafael Barros Gomes da Costa, Mariana Santana Santos Pereira Almeida-Lima, Jailma Melo-Silveira, Raniere Fagundes Albuquerque, Ivan Rui Lopes Leite, Edda Lisboa Rocha, Hugo Alexandre de Oliveira
author_sort	Costa, Leandro Silva
title	Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells
title_short	Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells
title_full	Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells
title_fullStr	Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells
title_full_unstemmed	Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells
title_sort	heterofucan from sargassum filipendula induces apoptosis in hela cells
publisher	MDPI
publishDate	2021
url	https://repositorio.ufrn.br/handle/123456789/31327
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Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells

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