Bloqueio do receptor NOP modula comportamento relacionado a ansiedade em camundongos expostos a estresse inescapável
Depression and anxiety frequently co-occurs and it has important clinical implications. Previous studies showed that activation of nociceptin/orphanin FQ receptor (NOP) elicits anxiolytic effects, while its blockade promotes consistent antidepressant actions. NOP antagonists are effective in reve...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/31205 |
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| Resumo: | Depression and anxiety frequently co-occurs and it has important clinical
implications. Previous studies showed that activation of nociceptin/orphanin FQ
receptor (NOP) elicits anxiolytic effects, while its blockade promotes consistent
antidepressant actions. NOP antagonists are effective in reversing footshocksinduced depressive-like behaviors, but their effects on stress-induced anxiety are still
nuclear.This study aimed to investigate the effects of the NOP antagonist SB-612111
on footshock stress-induced anxiety behaviors. Male Swiss mice were exposed to
inescapable electric footshock stress, and behavioral phenotype was screened
based on the ability to escape from footshock (ie., helpless or non helpless). Animals
were then treated with diazepam (1 mg/kg) and SB-612111 (0.1-10 mg/kg) and their
behavior was assessed in the elevated plus-maze (EPM) and open field test. When
compared to non stressed mice, helpless, but not non helpless, animals displayed
significant reduction in the time spent in and entries into open arms in the EPM.
Diazepam significantly increased open arms exploration in helpless, non helpless,
and non stressed mice. However, the treatment with the NOP antagonist SB-612111
was inactive in naïve mice, while it reversed anxiogenic-related behaviors in helpless,
and increased anxiety states in non helpless animals. No effects on locomotion were
observed. Helpless mice displayed increased anxiety compared to non stressed and
non helpless animals, thus it can be used as animal model to investigate
anxiety/depression co-morbidity. Additionally, SB-612111 modulated anxiety-like
behaviors in animals depending on individual stress susceptibility. Ultimately, NOP
antagonists can be useful for treating anxiety in depressive patients. |
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