Necrose mandibular associada ao uso de bifosfonato: relato de caso

Introduction:Bisphosphonates are medications that aim to reduce bone resorption by causing osteoclast apoptosis. For this reason, they are often used in patients with osteoporosis and in the treatment of cancer. However, despite the benefits associated with treatment with bispho...

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Principais autores: Souza Junior, Erasmo Freitas de, Silva, Janielma Azevedo, Soares, Maria do Socorro, Morais, Hécio Henrique Araújo de
Formato: article
Idioma:pt_BR
Publicado em: Universidade Federal do Rio Grande do Norte (UFRN)
Assuntos:
Bifosfonatos
Osteonecrose
Mandíbula
Bisphosphonates
Osteonecrosis
Jaw
Endereço do item:https://repositorio.ufrn.br/handle/123456789/31077
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spelling ri-123456789-310772020-12-27T08:10:43Z Necrose mandibular associada ao uso de bifosfonato: relato de caso Mandibular necrosis associated with biphosphonate use: case report Souza Junior, Erasmo Freitas de Silva, Janielma Azevedo Soares, Maria do Socorro Morais, Hécio Henrique Araújo de Bifosfonatos Osteonecrose Mandíbula Bisphosphonates Osteonecrosis Jaw Introduction:Bisphosphonates are medications that aim to reduce bone resorption by causing osteoclast apoptosis. For this reason, they are often used in patients with osteoporosis and in the treatment of cancer. However, despite the benefits associated with treatment with bisphosphonates, these drugs have been linked to maxillomandibular osteonecrosis, materializing as a worrying picture of public health concern. Objective:To present a clinical case of mandibular osteonecrosis associated with the use of bisphosphateafter extraction of a dental element, as well as to contribute to the discussions about the therapeutic possibilities of this disease. Case description:Male patient, 59 years old, referred to the Buccomaxillofacial Surgery and Traumatology service, two months after extraction of the dental element 45. The diagnosis was Bisphosphonate-Related Maxillomandibular Osteonecrosis, initially performed, the removal of existing traumas, as well as care for the exposed area. Subsequently, it was decided to remove the necrotic bone segment. Conclusions: The complex pathophysiology of the type of osteonecrosis studied requires that dental surgeons take measures in a timely manner and cause the least disturbance to patients' lives. Thus, the condition of the lesion should be assessed, with an indication for conservative therapy for early findings. Surgical debridement is recommended for the treatment of advanced and unresponsive diseases Introdução: Os bifosfonatos são medicamentos que objetivam reduzir a reabsorção óssea por provocarem a apoptose de osteoclastos. Por essa razão, são frequentemente empregados em pacientes com osteoporose e no tratamento do câncer. Contudo, apesar dos benefícios associados ao tratamento com bifosfonatos, esses medicamentos vêm sendo relacionados a osteonecrose maxilo-mandibular, materializando-se como um preocupante quadro de interesse à saúde pública. Objetivo: Apresentar um caso clínico de osteonecrose mandibular associada ao uso de bifosfanato, após extração de um elemento dentário, bem como contribuir com as discussões sobre as possibilidades terapêuticas desta enfermidade. Descrição do caso: Paciente do sexo masculino, 59 anos, encaminhado ao serviço de Cirurgia e Traumatologia Bucomaxilofacial dois meses após a extração do elemento dentário 45. O diagnóstico foi de Osteonecrose Maxilomandibular Relacionada a Bifosfonatos (OMRB), optando-se, inicialmente, pela remoção dos traumas existentes, como também o cuidado com a área exposta. Posteriormente, optou-se pela remoção do segmento ósseo necrótico. Conclusões: A complexa fisiopatologia da OMRB, exige dos cirurgiões dentistas a tomada de medidas em tempo oportuno e que cause o mínimo transtorno à vida dos pacientes. Assim, deve-se avaliar o estado da lesão, havendo indicação de terapia conservadora para os achados precoces. O desbridamento cirúrgico é aconselhado para o tratamento da doença avançada e não responsiva 2020-12-21T14:45:51Z 2020-12-21T14:45:51Z 2020-06-11 article SOUZA JUNIOR, Erasmo Freitas de; SILVA, Janielma Azevedo; SOARES, Maria do Socorro; MORAIS, Hécio Henrique Araújo de. Necrose mandibular associada ao uso de bifosfonato: relato de caso. Revista Ciência Plural, [s. l.], v. 6, n. 2, p. 205-219, 11 jun. 2020. Disponível em: https://periodicos.ufrn.br/rcp/article/view/19671. Acesso em: 05 out. 2020. http://dx.doi.org/10.21680/2446-7286.2020v6n2id19671 2446-7286 10.21680/2446-7286.2020v6n2id19671 https://repositorio.ufrn.br/handle/123456789/31077 pt_BR Attribution-NonCommercial-ShareAlike 3.0 Brazil http://creativecommons.org/licenses/by-nc-sa/3.0/br/ application/pdf Universidade Federal do Rio Grande do Norte (UFRN)
institution Repositório Institucional
collection RI - UFRN
language pt_BR
topic Bifosfonatos
Osteonecrose
Mandíbula
Bisphosphonates
Osteonecrosis
Jaw
spellingShingle Bifosfonatos
Osteonecrose
Mandíbula
Bisphosphonates
Osteonecrosis
Jaw
Souza Junior, Erasmo Freitas de
Silva, Janielma Azevedo
Soares, Maria do Socorro
Morais, Hécio Henrique Araújo de
Necrose mandibular associada ao uso de bifosfonato: relato de caso
description Introduction:Bisphosphonates are medications that aim to reduce bone resorption by causing osteoclast apoptosis. For this reason, they are often used in patients with osteoporosis and in the treatment of cancer. However, despite the benefits associated with treatment with bisphosphonates, these drugs have been linked to maxillomandibular osteonecrosis, materializing as a worrying picture of public health concern. Objective:To present a clinical case of mandibular osteonecrosis associated with the use of bisphosphateafter extraction of a dental element, as well as to contribute to the discussions about the therapeutic possibilities of this disease. Case description:Male patient, 59 years old, referred to the Buccomaxillofacial Surgery and Traumatology service, two months after extraction of the dental element 45. The diagnosis was Bisphosphonate-Related Maxillomandibular Osteonecrosis, initially performed, the removal of existing traumas, as well as care for the exposed area. Subsequently, it was decided to remove the necrotic bone segment. Conclusions: The complex pathophysiology of the type of osteonecrosis studied requires that dental surgeons take measures in a timely manner and cause the least disturbance to patients' lives. Thus, the condition of the lesion should be assessed, with an indication for conservative therapy for early findings. Surgical debridement is recommended for the treatment of advanced and unresponsive diseases
format article
author Souza Junior, Erasmo Freitas de
Silva, Janielma Azevedo
Soares, Maria do Socorro
Morais, Hécio Henrique Araújo de
author_facet Souza Junior, Erasmo Freitas de
Silva, Janielma Azevedo
Soares, Maria do Socorro
Morais, Hécio Henrique Araújo de
author_sort Souza Junior, Erasmo Freitas de
title Necrose mandibular associada ao uso de bifosfonato: relato de caso
title_short Necrose mandibular associada ao uso de bifosfonato: relato de caso
title_full Necrose mandibular associada ao uso de bifosfonato: relato de caso
title_fullStr Necrose mandibular associada ao uso de bifosfonato: relato de caso
title_full_unstemmed Necrose mandibular associada ao uso de bifosfonato: relato de caso
title_sort necrose mandibular associada ao uso de bifosfonato: relato de caso
publisher Universidade Federal do Rio Grande do Norte (UFRN)
publishDate 2020
url https://repositorio.ufrn.br/handle/123456789/31077
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