Evidence for age-related changes in the circadian activity rhythm of the diurnal primate Callithrix jacchus: a case report
Many cross-sectional studies have shown that circadian rhythms change with age, but such age-related modifications are gradual and may be insufficiently described by cross- sectional studies. In the present case study, circadian activity rhythm (CAR) was evaluated longitudinally, in both LD (12:12)...
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| Principais autores: | , , , , , |
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| Formato: | article |
| Idioma: | English |
| Publicado em: |
Taylor and Francis
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/31020 |
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| Resumo: | Many cross-sectional studies have shown that circadian rhythms change with age, but such age-related modifications are gradual and may be insufficiently described by cross- sectional studies. In the present case study, circadian activity rhythm (CAR) was evaluated longitudinally, in both LD (12:12) and LL conditions, on two occasions in a single male marmoset: when “adult” (3 y.o.) and when “old” (9 y.o.). When adult, the CAR synchronized with positive phase angles for the onset and offset of activity. In LL, the rhythm free-ran with τ < 24 h. When old, the animal showed a significant phase delay of its activity rhythm with respect to the LD cycle (t-test, p<0.01) and a reduction on total daily activity (t-test, p<0.01), with signs of lesser stability, greater fragmentation and some loss of photic synchronization. In LL, the period free-ran with τ > 24 h. We conclude that aging attenuates photic synchronization and the expression of a circadian activity rhythm in LL in the marmoset. Further studies with a larger number of individuals are needed to confirm these findings |
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