Alteração em hormônios de saciedade induzida por dieta e segurança de uso de inibidor de tripsina purificado de tamarindo com potencial anti-inflamatório em modelo experimental de obesidade
Obesity is a multifactorial disease, difficult to manage and that increases the risk of other diseases. In the search for adjuvants in classical lifestyle change therapy, trypsin inhibitors extracted from tamarind are prominent. The experimental models of obesity aim to mimic a highly unbalanced...
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| Formato: | doctoralThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/31018 |
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| Resumo: | Obesity is a multifactorial disease, difficult to manage and that increases the risk of
other diseases. In the search for adjuvants in classical lifestyle change therapy,
trypsin inhibitors extracted from tamarind are prominent. The experimental models of
obesity aim to mimic a highly unbalanced dietary pattern. To understand how this
pattern changes the hormonal balance that regulates energy metabolism, it evaluates
the effect of a diet with a high index and glycemic load (HGLI) without body weight,
cholecystokinin (CCK) and plasma leptin and with expression of its genes in the
small intestine , brain stem and visceral fat. Male Wistar rats (n = 10) were divided
into two groups, receiving a HGLI diet and another standard diet, both ad libitum, for
17 weeks. The animals that received HGLI diet increased the Body Mass Index (BMI)
and as circulating leptin and its genetic expression. There was no increase in plasma
CCK, but the group that received the HGLI diet showed greater expression of
CCK1R mRNA in the small intestine. The results suggested for leptin to stimulate the
expression of the CCK1R gene, increase the plasma increase in CCK, generate a
synergistic action induced by the receptor, which can cause postprandial satiety. To
understand how travel inhibitors can help treat obesity, perform a systematic review.
Twelve studies were found that involved the performance of travel inhibitors in satiety
in experimental models, whose main mechanism of convergent action for modulation,
mainly CCK. In addition, travel inhibitors can act on biochemical parameters related
to obesity, emerging as promising molecules. Tamarindo's Trypsin Inhibitor has been
extensively studied in the obesity model, showing several fronts of action, both in its
isolated (TTI) and purified (pTTI) states. TTI has already been analyzed from a
toxicological point of view. Thus, in this study studied or in the pTTI for toxic effects,
with involvement in the organs involved in its metabolism (liver and pancreas) and in
the tissues most affected by the obesity model (intestine and visceral adipose tissue).
For this, pTTI was obtained and Wistar rats (n = 15) were divided into control groups,
fed a standard diet; obese group, eating a HGLI diet; experimental group, fed with
HGLI and treated with pTTI. The treatment lasted 10 days. Histopathological and
stereological analyzes of tissues were performed. Note that the administration of
pTTI does not affect the stereological parameters of the analyzed tissues, also acting
as a protective factor of the intestinal mucosa. This finding leads one to believe that
the pTTI, in addition to its biological activities, is safe in terms of use. |
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