Potencial anticariogênico de taninos de espécies florestais
The study ofcompounds from secondary plant metabolism can increase our ability to understand the pharmacological potential of tropical flora. The presence of tannins arouses pharmaceutical interest in several plant species, based on the principle of popular use, and their antimicrobial, a...
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Taninos vegetais Substâncias bioativas Atividade antimicrobiana Cáries dentarias Bactérias cariogênicas. Natural tannins Bioactive substances Antimicrobial activity Dental caries Cariogenics bacterias |
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Taninos vegetais Substâncias bioativas Atividade antimicrobiana Cáries dentarias Bactérias cariogênicas. Natural tannins Bioactive substances Antimicrobial activity Dental caries Cariogenics bacterias Marques, Sarah Rebeka Rodrigues Potencial anticariogênico de taninos de espécies florestais |
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The study ofcompounds from secondary plant metabolism can increase our ability to understand the pharmacological potential of tropical flora. The presence of tannins arouses pharmaceutical interest in several plant species, based on the principle of popular use, and their antimicrobial, antioxidant, antiviral and anti-tumor properties of tannins, which are already well known and documented. This study aimed to extract, quantify, characterize chemically and check for antibacterial activity against microorganisms of dental importance in tannins extracted from the bark of four forest species cultivated in the Brazilian semiarid region: Acacia mangiumWilld., Azadirachta indicaA. Juss Mimosa tenuifloraWilld, Mimosa caesalpiniifolia Benth.. The extractions were carried out in hot water and the total solids content (TST), Stiasny index (IS) and the condensed tannin content (TTC) were determined. The chemical characterization of the extracts was carried out using infrared spectrometry with Fourrier transform. The evaluation of antibacterial activity was performed using the Minimum Inhibitory Concentration (MIC) assay for the species Streptococcus mutans(UA159), Lactobacillus acidophilus(ATCC IAL523), Lactobacillus casei(ATCC 193) and Candida albicans(SC5314). The quantification of the extracts showed that M. tenuifloraand A. mangiumpresented higher percentages of TTC (23.40% and 12.41%, respectively), indicating the potential for tannin production on an industrial scale. Although M. caesalpiniifoliahad a low TTC (8.38%), this species showed a high IS (91.27%), characterized by a high degree of purity in its tannins. No evaluated extract showedinhibitory activity against the tested microorganisms (MIC> 2500 μg / mL). Although it was possible to observe from the FTIR a preliminary phytochemical profile of the extracts, such as the presence of complex polyphenolic compounds, the ausenceof antimicrobial activity for the species tested may be related to a combination of factors that can inhibit antimicrobial activity, such as presence of other phytochemicals with different polarities |
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Carnaval, Tatiane Kelly Barbosa De Azevedo |
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Carnaval, Tatiane Kelly Barbosa De Azevedo Marques, Sarah Rebeka Rodrigues |
| format |
masterThesis |
| author |
Marques, Sarah Rebeka Rodrigues |
| author_sort |
Marques, Sarah Rebeka Rodrigues |
| title |
Potencial anticariogênico de taninos de espécies florestais |
| title_short |
Potencial anticariogênico de taninos de espécies florestais |
| title_full |
Potencial anticariogênico de taninos de espécies florestais |
| title_fullStr |
Potencial anticariogênico de taninos de espécies florestais |
| title_full_unstemmed |
Potencial anticariogênico de taninos de espécies florestais |
| title_sort |
potencial anticariogênico de taninos de espécies florestais |
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Universidade Federal do Rio Grande do Norte |
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2020 |
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https://repositorio.ufrn.br/handle/123456789/30626 |
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AT marquessarahrebekarodrigues potencialanticariogenicodetaninosdeespeciesflorestais |
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1773963991095181312 |
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ri-123456789-306262020-11-29T07:46:38Z Potencial anticariogênico de taninos de espécies florestais Marques, Sarah Rebeka Rodrigues Carnaval, Tatiane Kelly Barbosa De Azevedo Calegari, Leandro Braga, Renata Martins Taninos vegetais Substâncias bioativas Atividade antimicrobiana Cáries dentarias Bactérias cariogênicas. Natural tannins Bioactive substances Antimicrobial activity Dental caries Cariogenics bacterias The study ofcompounds from secondary plant metabolism can increase our ability to understand the pharmacological potential of tropical flora. The presence of tannins arouses pharmaceutical interest in several plant species, based on the principle of popular use, and their antimicrobial, antioxidant, antiviral and anti-tumor properties of tannins, which are already well known and documented. This study aimed to extract, quantify, characterize chemically and check for antibacterial activity against microorganisms of dental importance in tannins extracted from the bark of four forest species cultivated in the Brazilian semiarid region: Acacia mangiumWilld., Azadirachta indicaA. Juss Mimosa tenuifloraWilld, Mimosa caesalpiniifolia Benth.. The extractions were carried out in hot water and the total solids content (TST), Stiasny index (IS) and the condensed tannin content (TTC) were determined. The chemical characterization of the extracts was carried out using infrared spectrometry with Fourrier transform. The evaluation of antibacterial activity was performed using the Minimum Inhibitory Concentration (MIC) assay for the species Streptococcus mutans(UA159), Lactobacillus acidophilus(ATCC IAL523), Lactobacillus casei(ATCC 193) and Candida albicans(SC5314). The quantification of the extracts showed that M. tenuifloraand A. mangiumpresented higher percentages of TTC (23.40% and 12.41%, respectively), indicating the potential for tannin production on an industrial scale. Although M. caesalpiniifoliahad a low TTC (8.38%), this species showed a high IS (91.27%), characterized by a high degree of purity in its tannins. No evaluated extract showedinhibitory activity against the tested microorganisms (MIC> 2500 μg / mL). Although it was possible to observe from the FTIR a preliminary phytochemical profile of the extracts, such as the presence of complex polyphenolic compounds, the ausenceof antimicrobial activity for the species tested may be related to a combination of factors that can inhibit antimicrobial activity, such as presence of other phytochemicals with different polarities Estudar os compostos provenientes do metabolismo secundário das plantas podeaumentar a nossa capacidade de entender o potencial farmacológico da flora tropical. A presençade taninos desperta interesse farmacêutico em diversasespécies vegetais, partindo-se do princípio do uso popular,e das suas propriedades antimicrobiana, antioxidante, antiviral e antitumoraldos taninos, que já são bastante conhecidas e documentadas. Este estudo objetivou extrair, quantificar, caracterizar quimicamente e verificarse háatividade antibacterianafrente àmicro-organismos de importância odontológica em taninos extraídos das cascas de quatro espécies florestais cultivadas em região semiárida brasileira:Acaciamangium Willd., Azadirachta indica A. JussMimosa tenuifloraWilld, Mimosa caesalpiniifoliaBenth..As extrações foramrealizadas em água quentee foram determinados o teor de sólidos totais(TST), índice de Stiasny(IS) e o teor de taninos condensados(TTC). Foirealizada a caracterização química dos extratos mediante espectrometria de infravermelho com transformada de Fourrier. A avaliação da atividade antibacterianafoirealizada por meiode ensaio deConcentração Inibitória Mínima(CIM)para asespéciesStreptococcus mutans(UA159),Lactobacillus acidophilus(ATCC IAL523),Lactobacillus casei(ATCC 193)eCandida albicans(SC5314).A quantificação dos extratos mostrou que M. tenuiflora eA. mangiumapresentaram maiores percentuais de TTC (23,40% e 12,41%, respectivamente), indicando potencial para produção de taninos em escala industrial. Embora a M. caesalpiniifoliatenha apresentado baixo TTC (8,38%), esta espécie apresentou alto IS (91,27%), caracterizando-se pelo alto grau de pureza em seus taninos.Nenhum extrato avaliado apresentou atividade inibitória contra os microrganismos testados (CIM> 2500 μg/mL). Embora tenha sido possível observar a partirdo FTIR um perfil fitoquímico preliminar dos extratos, como a presença de compostos polifenólicos complexos, a ausência de atividade antimicrobiana para as espécies testadas pode estar relacionadaà uma combinação de fatores, como a presença de fitoquímicoscom diferentes polaridades, e a características taxonômicas especificas dos micro-organismos testados 2020-11-23T10:58:02Z 2020-11-23T10:58:02Z 2020-07-31 masterThesis MARQUES, Sarah Rebeka Rodrigues. Potencial anticariogênico de taninos de espécies florestais. 2020. 55f. Dissertação (Mestrado em Ciências Florestais) - Universidade Federal do Rio Grande do Norte, Universidade Federal do Rio Grande do Norte, Natal, 2020. https://repositorio.ufrn.br/handle/123456789/30626 pt_BR Acesso Aberto application/pdf Universidade Federal do Rio Grande do Norte Brasil UFRN PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS FLORESTAIS |