Análise de células dendríticas, mastócitos e vascularização na doença periodontal biofilme induzida em idosos
The elderly's microbiota and immune system show some changes, favoring the onset of infections and inflammatory diseases. Periodontal disease is an example, permeating between immediate and adaptative stages, it can have changes in its evolution with human aging. Understanding periodontal di...
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| Formato: | doctoralThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/29741 |
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| Resumo: | The elderly's microbiota and immune system show some changes, favoring the onset of
infections and inflammatory diseases. Periodontal disease is an example, permeating between
immediate and adaptative stages, it can have changes in its evolution with human aging.
Understanding periodontal disease and its relationship with the life cycle is important for
prevention, treatment and cure. This study aims to assess the amount of mast cells (tryptase),
immature dendritic cells (CD1a), mature dendritic cells (CD83) and blood vessels (CD34) in
154 healthy and sick periodontal tissues (27 elderly and 127 adults). The
immunohistochemistry technique was used through the immunostaining of CD1a, CD83,
tryptase and CD34, being counted in 5 fields with a greater number of positive cells, in the
1000x increase. For CD34, the microvascular area and perimeter were also calculated for all
blood vessels present, and for vessels with the presence of high vascular endothelium. There
was no difference in the immunostaining of dendritic cells, mast cells and the amount of blood
vessels in the gingival tissues, between cases of clinically healthy gingiva, biofilm-induced
gingivitis and stages II, III and IV periodontitis, evaluating the age groups: adults and elderly.
Immature dendritic cells are more numerous in the elderly with the clinical picture of
gingivitis and periodontitis. Adults with biofilm-induced gingivitis have a greater amount of
blood vessels than the elderly group. The microvascular area and the microvascular perimeter
of the blood vessels with the high vascular endothelium were larger in the elderly in cases of
gingivitis. This study concluded that in this sample there was no difference in the amount of
immature and mature dendritic cells, mast cells in periodontal disease within the age groups,
however, immature dendritic cells are more present in the elderly and may be related to some
functional decrease. Regarding blood vessels, there are HEVs in adults and the elderly, with
no difference between diagnoses. In the elderly with gingivitis there is an increase in the
microvascular area and microvascular perimeter, requiring studies that justify this difference. |
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